Product Name
ADAM8, cDNA Clone
Full Product Name
ADAM8 cDNA Clone
Product Gene Name
ADAM8 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCGCGGCC TCGGGCTCTG GCTGCTGGGC GCGATGATGC TGCCTGCGAT TGCCCCCAGC CGGCCCTGGG CCCTCATGGA GCAGTATGAG GTCGTGTTGC CGCGGCGTCT GCCAGGCCCC CGAGTCCGCC GAGCTCTGCC CTCCCACTTG GGCCTGCACC CAGAGAGGGT GAGCTACGTC CTTGGGGCCA CAGGGCACAA CTTCACCCTC CACCTGCGGA AGAACAGGGA CCTGCTGGGT TCCGGCTACA CAGAGACCTA TACGGCTGCC AATGGCTCCG AGGTGACGGA GCAGCCTCGC GGGCAGGACC ACTGCTTCTA CCAGGGCCAC GTAGAGGGGT ACCCGGACTC AGCCGCCAGC CTCAGCACCT GTGCCGGCCT CAGGGGTTTC TTCCAGGTGG GGTCAGACCT GCACCTGATC GAGCCCCTGG ATGAAGGTGG CGAGGGCGGA CGGCACGCCG TGTACCAGGC TGAGCACCTG CTGCAGACGG CCGGGACCTG CGGGGTCAGC GACGACAGCC TGGGCAGCCT CCTGGGACCC CGGACGGCAG CCGTCTTCAG GCCTCGGCCC GGGGACTCTC TGCCATCCCG AGAGACCCGC TACGTGGAGC TGTATGTGGT CGTGGACAAT GCAGAGTTCC AGATGCTGGG GAGCGAAGCA GCCGTGCGTC ATCGGGTGCT GGAGGTGGTG AATCACGTGG ACAAGCTATA TCAGAAACTC AACTTCCGTG TGGTCCTGGT GGGCCTGGAG ATTTGGAATA GTCAGGACAG GTTCCACGTC AGCCCCGACC CCAGTGTCAC ACTGGAGAAC CTCCTGACCT GGCAGGCACG GCAACGGACA CGGCGGCACC TGCATGACAA CGTACAGCTC ATCACGGGTG TCGACTTCAC CGGGACTACT GTGGGGTTTG CCAGGGTGTC CGCCATGTGC TCCCACAGCT CAGGGGCTGT GAACCAGGAC CACAGCAAGA ACCCCGTGGG CGTGGCCTGC ACCATGGCCC ATGAGATGGG CCACAACCTG GGCATGGACC ATGATGAGAA CGTCCAGGGC TGCCGCTGCC AGGAACGCTT CGAGGCCGGC CGCTGCATCA TGGCAGGCAG CATTGGCTCC AGTTTCCCCA GGATGTTCAG TGACTGCAGC CAGGCCTACC TGGAGAGCTT TTTGGAGCGG CCGCAGTCGG TGTGCCTCGC CAACGCCCCT GACCTCAGCC ACCTGGTGGG CGGCCCCGTG TGTGGGAACC TGTTTGTGGA GCGTGGGGAG CAGTGCGACT GCGGCCCCCC CGAGGACTGC CGGAACCGCT GCTGCAACTC TACCACCTGC CAGCTGGCTG AGGGGGCCCA GTGTGCGCAC GGTACCTGCT GCCAGGAGTG CAAGGTGAAG CCGGCTGGTG AGCTGTGCCG TCCCAAGAAG GACATGTGTG ACCTCGAGGA GTTCTGTGAC GGCCGGCACC CTGAGTGCCC GGAAGACGCC TTCCAGGAGA ACGGCACGCC CTGCTCCGGG GGCTACTGCT ACAACGGGGC CTGTCCCACA CTGGCCCAGC AGTGCCAGGC CTTCTGGGGG CCAGGTGGGC AGGCTGCCGA GGAGTCCTGC TTCTCCTATG ACATCCTACC AGGCTGCAAG GCCAGCCGGT ACAGGGCTGA CATGTGTGGC GTTCTGCAGT GCAAGGGTGG GCAGCAGCCC CTGGGGCGTG CCATCTGCAT CGTGGATGTG TGCCACGCGC TCACCACAGA GGATGGCACT GCGTATGAAC CAGTGCCCGA GGGCACCCGG TGTGGACCAG AGAAGGTTTG CTGGAAAGGA CGTTGCCAGG ACTTACACGT TTACAGATCC AGCAACTGCT CTGCCCAGTG CCACAACCAT GGGGTGTGCA ACCACAAGCA GGAGTGCCAC TGCCACGCGG GCTGGGCCCC GCCCCACTGC GCGAAGCTGC TGACTGAGGT GCACGCAGCG TCCGGGAGCC TCCCCGTCCT CGTGGTGGTG GTTCTGGTGC TCCTGGCAGT TGTGCTGGTC ACCCTGGCAG GCATCATCGT CTACCGCAAA GCCCGGAGCC GCATCCTGAG CAGGAACGTG GCTCCCAAGA CCACAATGGG GCGCTCCAAC CCCCTGTTCC ACCAGGCTGC CAGCCGCGTG CCGGCCAAGG GCGGGGCTCC AGCCCCATCC AGGGGCCCCC AAGAGCTGGT CCCCACCACC CACCCGGGCC AGCCCGCCCG ACACCCGGCC TCCTCGGTGG CTCTGAAGAG GCCGCCCCCT GCTCCTCCGG TCACTGTGTC CAGCCCACCC TTCCCAGTTC CTGTCTACAC CCGGCAGGCA CCAAAGCAGG TCATCAAGCC AACGTTCGCA CCCCCAGTGC CCCCAGTCAA ACCCGGGGCT GGTGCGGCCA ACCCTGGTCC AGCTGAGGGT GCTGTTGGCC CAAAGGTTGC CCTGAAGCCC CCCATCCAGA GGAAGCAAGG AGCCGGAGCT CCCACAGCAC CCTAG
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADAM8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
NCBI Accession #
BC115404
[Other Products]
UniProt Secondary Accession #
B4DVM6; H0YL36; H0YLR0; H0YN39[Other Products]
UniProt Related Accession #
P78325[Other Products]
Molecular Weight
80,262 Da
NCBI Official Full Name
Homo sapiens ADAM metallopeptidase domain 8, mRNA
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 8
NCBI Official Symbol
ADAM8 [Similar Products]
NCBI Official Synonym Symbols
MS2; CD156; CD156a
[Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 8
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 8
UniProt Synonym Protein Names
Cell surface antigen MS2; CD_antigen: CD156a
Protein Family
Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name
ADAM8 [Similar Products]
UniProt Synonym Gene Names
MS2; ADAM 8 [Similar Products]
UniProt Entry Name
ADAM8_HUMAN
NCBI Summary for ADAM8
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
UniProt Comments for ADAM8
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion
Research Articles on ADAM8
1. ADAM8 causes temozolomide resistance in glioblastoma cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met
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