Full Product Name
Cdkl5, CT (Cdkl5, Cyclin-dependent kinase-like 5)
Product Synonym Names
Anti -Cdkl5, CT (Cdkl5, Cyclin-dependent kinase-like 5)
Product Gene Name
anti-CDKL5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (18443725..18671749). Location: Xp22
3D Structure
ModBase 3D Structure for O76039
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
Mouse Cdkl5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 729-758 amino acids from the C-terminal region of human Mouse Cdkl5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CDKL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDKL5 antibody
Cdkl5 mediates phosphorylation of MECP2 (By similarity).
Product Categories/Family for anti-CDKL5 antibody
Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-CDKL5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CDKL5 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for CDKL5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001032420.1
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NCBI GenBank Nucleotide #
NM_001037343.1
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UniProt Primary Accession #
O76039
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UniProt Secondary Accession #
Q14198; Q5H985; Q8IYC7; Q9UJL6; G9B9X4[Other Products]
UniProt Related Accession #
O76039[Other Products]
Molecular Weight
115,538 Da[Similar Products]
NCBI Official Full Name
cyclin-dependent kinase-like 5
NCBI Official Synonym Full Names
cyclin-dependent kinase-like 5
NCBI Official Symbol
CDKL5 [Similar Products]
NCBI Official Synonym Symbols
ISSX; STK9; EIEE2
[Similar Products]
NCBI Protein Information
cyclin-dependent kinase-like 5; serine/threonine kinase 9; serine/threonine-protein kinase 9; cyclin dependent kinase 5 transcript
UniProt Protein Name
Cyclin-dependent kinase-like 5
UniProt Synonym Protein Names
Serine/threonine-protein kinase 9
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDKL5 [Similar Products]
UniProt Synonym Gene Names
STK9 [Similar Products]
UniProt Entry Name
CDKL5_HUMAN
NCBI Summary for CDKL5
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CDKL5
CDKL5: a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.
Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Kinase, protein; EC 2.7.11.22; CMGC group; CDKL family
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: dendrite cytoplasm; nucleoplasm; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; Rac GTPase binding; kinase activity; ATP binding; protein kinase activity
Biological Process: regulation of cell cycle; positive regulation of axon extension; protein amino acid autophosphorylation; regulation of dendrite development; neuron migration; positive regulation of dendrite morphogenesis; protein amino acid phosphorylation
Disease: Angelman Syndrome; Epileptic Encephalopathy, Early Infantile, 2
Research Articles on CDKL5
1. 3 known & 3 new (V966Im A1911V, H589H)mutations in the C-terminal domain of CDKL5 were found in Indian patients with Rett syndrome negative for MECP2.
Precautions
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Disclaimer
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