Product Name
SDHA, cDNA Clone
Popular Item
Full Product Name
SDHA cDNA Clone
Product Gene Name
SDHA cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtcggggg tccggggcct gtcgcggctg ctgagcgctc ggcgcctggc gctggccaag gcgtggccaa cagtgttgca aacaggaacc cgaggttttc acttcactgt tgatgggaac aagagggcat ctgctaaagt ttcagattcc atttctgctc agtatccagt agtggatcat gaatttgatg cagtggtggt aggcgctgga ggggcaggct tgcgagctgc atttggcctt tctgaggcag ggtttaatac agcatgtgtt accaagctgt ttcctaccag gtcacacact gttgcagcac agggaggaat caatgctgct ctggggaaca tggaggagga caactggagg tggcatttct acgacaccgt gaagggctcc gactggctgg gggaccagga tgccatccac tacatgacgg agcaggcccc cgccgccgtg gtcgagctag aaaattatgg catgccgttt agcagaactg aagatgggaa gatttatcag cgtgcatttg gtggacagag cctcaagttt ggaaagggcg ggcaggccca tcggtgctgc tgtgtggctg atcggactgg ccactcgcta ttgcacacct tatatggaag gtctctgcga tatgatacca gctattttgt ggagtatttt gccttggatc tcctgatgga gaatggggag tgccgtggtg tcatcgcact gtgcatagag gacgggtcca tccatcgcat aagagcaaag aacactgttg ttgccacagg aggctacggg cgcacctact tcagctgcac gtctgcccac accagcactg gcgacggcac ggccatgatc accagggcag gccttccttg ccaggaccta gagtttgttc agttccaccc cacaggcata tatggtgctg gttgtctcat tacggaagga tgtcgtggag agggaggcat tctcattaac agtcaaggcg aaaggtttat ggagcgatac gcccctgtcg cgaaggacct ggcgtctaga gatgtggtgt ctcggtccat gactctggag atccgagaag gaagaggctg tggccctgag aaagatcacg tctacctgca gctgcaccac ctacctccag agcagctggc cacgcgcctg cctggcattt cagagacagc catgatcttc gctggcgtgg acgtcacgaa ggagccgatc cctgtcctcc ccaccgtgca ttataacatg ggcggcattc ccaccaacta caaggggcag gtcctgaggc acgtgaatgg ccaggatcag attgtgcccg gcctgtacgc ctgtggggag gccgcctgtg cctcggtaca tggtgccaac cgcctcgggg caaactcgct cttggacctg gttgtctttg gtcgggcatg tgccctgagc atcgaagagt catgcaggcc tggagataaa gtccctccaa ttaaaccaaa cgctggggaa gaatctgtca tgaatcttga caaattgaga tttgctgatg gaagcataag aacatcggaa ctgcgactca gcatgcagaa gtcaatgcaa aatcatgctg ccgtgttccg tgtgggaagc gtgttgcaag aaggttgtgg gaaaatcagc aagctctatg gagacctaaa gcacctgaag acgttcgacc ggggaatggt ctggaacacg gacctggtgg agaccctgga gctgcagaac ctgatgctgt gtgcgctgca gaccatctac ggagcagagg cacggaagga gtcacggggc gcgcatgcca gggaagacta caaggtgcgg attgatgagt acgattactc caagcccatc caggggcaac agaagaagcc ctttgaggag cactggagga agcacaccct gtcctatgtg gacgttggca ctgggaaggt cactctggaa tatagacccg tgatcgacaa aactttgaac gaggctgact gtgccaccgt cccgccagcc attcgctcct actga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SDHA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SDHA. It may not necessarily be applicable to this product.
NCBI Accession #
BC001380
[Other Products]
UniProt Secondary Accession #
Q16395; Q59GW8; Q8IW48; Q9UMY5; A8K5J6; B4DJ60; E9PBJ5[Other Products]
UniProt Related Accession #
P31040[Other Products]
Molecular Weight
56,650 Da
NCBI Official Full Name
Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp), mRNA
NCBI Official Synonym Full Names
succinate dehydrogenase complex flavoprotein subunit A
NCBI Official Symbol
SDHA [Similar Products]
NCBI Official Synonym Symbols
FP; PGL5; SDH1; SDH2; SDHF; CMD1GG
[Similar Products]
NCBI Protein Information
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
UniProt Protein Name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
UniProt Synonym Protein Names
Flavoprotein subunit of complex II; Fp
Protein Family
Succinate dehydrogenase
UniProt Gene Name
SDHA [Similar Products]
UniProt Synonym Gene Names
SDH2; SDHF; Fp [Similar Products]
UniProt Entry Name
SDHA_HUMAN
NCBI Summary for SDHA
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
UniProt Comments for SDHA
SDHA: is the catalytic subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. Complex II contains four subunits: the flavoprotein catalytic subunit SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interaction with SDH5 is required for FAD attachment. Responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHA cause defective mitochondrial oxidative phosphorylation, giving rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. Acetylation of SDHA may control entry of the substrate into the active site, thus regulating its enzymatic activity. Acetylated SDHA may be a SIRT3 substrate SIRT3 is a mitochondrial NAD(+)-dependent deacetylase. Increased succinate levels as a consequence of SDH deficiency inhibit hypoxia inducible factor-1alpha (HIF-1alpha) prolyl hydroxylases leading to sustained HIF-1alpha expression in tumours. Defects in SDHA cause of Leigh syndrome, a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
Protein type: Oxidoreductase; Tumor suppressor; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial
Chromosomal Location of Human Ortholog: 5p15
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex II; mitochondrion
Molecular Function: protein binding; succinate dehydrogenase (ubiquinone) activity; succinate dehydrogenase activity
Biological Process: nervous system development; succinate metabolic process; tricarboxylic acid cycle
Disease: Cardiomyopathy, Dilated, 1gg; Leigh Syndrome; Mitochondrial Complex Ii Deficiency; Paragangliomas 5
Research Articles on SDHA
1. our findings provide further evidence that patients with KIT/PDGFRA wild-type SDH-deficient GIST harboring SDHA mutations experience good survival outcomes
Precautions
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Disclaimer
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