Product Name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha), Recombinant Protein
Full Product Name
Recombinant Rat Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha)
Product Gene Name
Sdha recombinant protein
[Similar Products]
Product Synonym Gene Name
Sdha[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
36-656aa, Full Length of Mature Protein
Sequence
SAKVSDAIST QYPVVDHEFD AVVVGAGGAG LRAAFGLSEA GFNTACLTKL FPTRSHTVAA QGGINAALGN MEEDNWRWHF YDTVKGSDWL GDQDAIHYMT EQAPASVVEL ENYGMPFSRT EDGRIYQRAF GGQSLKFGKG GQAHRCCCVA DRTGHSLLHT LYGRSLRYDT SYFVEYFALD LLMENGECRG VIALCIEDGS IHRIRAKNTI IATGGYGRTY FSCTSAHTST GDGTAMVTRA GLPCQDLEFV QFHPTGIYGA GCLITEGCRG EGGILINSQG ERFMERYAPV AKDLASRDVV SRSMTLEIRE GRGCGPEKDH VYLQLHHLPP EQLATRLPGI SETAMIFAGV DVTKEPIPVL PTVHYNMGGI PTNYKGQVLK HVNGQDQIVP GLYACGEAAC ASVHGANRLG ANSLLDLVVF GRACALSIAE SCRPGDKVPP IKANAGEESV MNLDKLRFAD GSVRTSELRL SMQKSMQSHA AVFRVGSVLQ EGCEKVSQLY GDLQHLKTFD RGMVWNTDLV ETLELQNLML CALQTIYGAE ARKESRGAHA REDYKVRIDE YDYSKPIEGQ QKKPFAEHWR KHTLSYVDTK TGKVTLDYRP VIDKTLNEAD CATVPPAIRS Y
3D Structure
ModBase 3D Structure for Q920L2
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Sdha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Sdha recombinant protein
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29.
NCBI/Uniprot data below describe general gene information for Sdha. It may not necessarily be applicable to this product.
NCBI Accession #
NP_569112.1
[Other Products]
NCBI GenBank Nucleotide #
NM_130428.1
[Other Products]
UniProt Primary Accession #
Q920L2
[Other Products]
UniProt Related Accession #
Q920L2[Other Products]
Molecular Weight
71,615 Da
NCBI Official Full Name
succinate dehydrogenase
NCBI Official Synonym Full Names
succinate dehydrogenase complex flavoprotein subunit A
NCBI Official Symbol
Sdha [Similar Products]
NCBI Protein Information
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
UniProt Protein Name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
UniProt Synonym Protein Names
Flavoprotein subunit of complex II; Fp
Protein Family
Succinate dehydrogenase
UniProt Gene Name
Sdha [Similar Products]
UniProt Synonym Gene Names
Fp [Similar Products]
NCBI Summary for Sdha
subunit of the mitochondrial succinate hehydrogenase that is involved in the oxidation of succinate; mutation of human homolog is associated with Leigh syndrome [RGD, Feb 2006]
UniProt Comments for Sdha
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.
Research Articles on Sdha
1. Data suggest activation/acetylation of Sdha in skeletal muscle can be regulated by diet; maternal low-protein leads to inactivation of Sdha; postnatal high-fat leads to further inactivation of Sdha; this increases susceptibility to type 2 diabetes.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
