Full Product Name
SPG21 Antibody; HRP conjugated
Product Synonym Names
Maspardin; Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Spastic paraplegia 21 protein; SPG21; ACP33; BM-019; GL010
Product Gene Name
anti-SPG21 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NZD8
Purity/Purification
>95%,Protein G purified
Immunogen
Recombinant human Maspardin protein
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83838
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SPG21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPG21 antibody
May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
Applications Tested/Suitable for anti-SPG21 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SPG21. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001121361.1
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NCBI GenBank Nucleotide #
NM_001127889.4
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UniProt Primary Accession #
Q9NZD8
[Other Products]
UniProt Secondary Accession #
Q6ZMB6; B4DW44[Other Products]
UniProt Related Accession #
Q9NZD8[Other Products]
Molecular Weight
31,585 Da
NCBI Official Full Name
maspardin isoform a
NCBI Official Synonym Full Names
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
NCBI Official Symbol
SPG21 [Similar Products]
NCBI Official Synonym Symbols
MAST; ACP33; GL010; BM-019
[Similar Products]
NCBI Protein Information
maspardin
UniProt Protein Name
Maspardin
UniProt Synonym Protein Names
Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Spastic paraplegia 21 protein
UniProt Gene Name
SPG21 [Similar Products]
UniProt Synonym Gene Names
ACP33 [Similar Products]
UniProt Entry Name
SPG21_HUMAN
NCBI Summary for SPG21
The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
UniProt Comments for SPG21
SPG21: May play a role as a negative regulatory factor in CD4- dependent T-cell activation. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21 (SPG21); also known as Mast syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG21 is associated with dementia and other central nervous system abnormalities. Subtle childhood abnormalities may be present, but the main features develop in early *****hood. The disease is slowly progressive, and cerebellar and extrapyramidal signs are also found in patients with advanced disease. Patients have a thin corpus callosum and white-matter abnormalities. Belongs to the AB hydrolase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm; cytosol; endosome membrane; intracellular membrane-bound organelle; trans-Golgi network transport vesicle
Molecular Function: CD4 receptor binding; protein binding
Biological Process: antigen receptor-mediated signaling pathway
Disease: Mast Syndrome
Research Articles on SPG21
1. HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner.
Precautions
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Disclaimer
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