Product Name
BOB / GPR15, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human BOB / GPR15
Product Synonym Names
Anti-BOB / GPR15 Antibody (Extracellular Domain) IHC-plus; GPR15; Brother of Bonzo; G protein-coupled receptor 15; G-protein coupled receptor 15; BOB; Gpr-15; Human BOB; GPR15
Product Gene Name
anti-BOB antibody
[Similar Products]
Product Synonym Gene Name
GPR15[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P49685
Species Reactivity
Gibbon, Chimpanzee, Gorilla, Human
Predicted Reactivity: Monkey, Bovine, Pig, Rabbit (at least 90% immunogen sequence identity)
Specificity
Human GPR15. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic 19 amino acid peptide from 2nd extracellular domain of human GPR15. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Panda (100%); Marmoset, Bovine, Elephant, Rabbit, Pig (95%); Horse (89%).
Immunogen Type
Synthetic peptide
Immunogen
BOB / GPR15 antibody was raised against synthetic 19 amino acid peptide from 2nd extracellular domain of human GPR15. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Panda (100%); Marmoset, Bovine, Elephant, Rabbit, Pig (95%); Horse (89%); Mouse, Bat (84%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-BOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BOB antibody
G protein-coupled receptor GPR15 is an Orphan-A GPCR with an unknown ligand. Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to
biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells.
Product Categories/Family for anti-BOB antibody
Subfamily:-Orphan-A">Family: GPCR
Subfamily: Orphan-A
Applications Tested/Suitable for anti-BOB antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-BOB antibody
IHC-P (10 ug/ml)
Usage: Antigen retrieval requires Proteinase K treatment.
Immunohistochemistry (IHC) of anti-BOB antibody
Anti-GPR15 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry (IHC) of anti-BOB antibody
Anti-GPR15 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NCBI/Uniprot data below describe general gene information for BOB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005281.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005290.2
[Other Products]
UniProt Primary Accession #
P49685
[Other Products]
UniProt Secondary Accession #
Q3MIL4; Q6ISN6[Other Products]
UniProt Related Accession #
P49685[Other Products]
Molecular Weight
40,787 Da
NCBI Official Full Name
G-protein coupled receptor 15
NCBI Official Synonym Full Names
G protein-coupled receptor 15
NCBI Official Symbol
GPR15 [Similar Products]
NCBI Official Synonym Symbols
BOB
[Similar Products]
NCBI Protein Information
G-protein coupled receptor 15; brother of Bonzo
UniProt Protein Name
G-protein coupled receptor 15
UniProt Synonym Protein Names
Brother of Bonzo; BoB
UniProt Gene Name
GPR15 [Similar Products]
UniProt Synonym Gene Names
BoB [Similar Products]
UniProt Entry Name
GPR15_HUMAN
NCBI Summary for BOB
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
UniProt Comments for BOB
GPR15: Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q11.2-q13.1
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway
Research Articles on BOB
1. Data indicate that orphan receptor GPR15/BOB is expressed by macrophages in synovial tissue and on monocytes and neutrophils in peripheral blood, and expression is up-regulated in arthritis (RA)patients
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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