Product Synonym Names
AC; ACDase; ASAH; PHP; PHP32; SMAPME
Product Gene Name
anti-ASAH1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13510
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human ASAH1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-ASAH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASAH1 antibody
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy.
Applications Tested/Suitable for anti-ASAH1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ASAH1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for ASAH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001120977.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001127505.2
[Other Products]
UniProt Primary Accession #
Q13510
[Other Products]
UniProt Secondary Accession #
Q6W898; Q96AS2; E9PDS0[Other Products]
UniProt Related Accession #
Q13510[Other Products]
NCBI Official Full Name
acid ceramidase isoform c
NCBI Official Synonym Full Names
N-acylsphingosine amidohydrolase 1
NCBI Official Symbol
ASAH1 [Similar Products]
NCBI Official Synonym Symbols
AC; PHP; ASAH; PHP32; ACDase; SMAPME
[Similar Products]
NCBI Protein Information
acid ceramidase
UniProt Protein Name
Acid ceramidase
UniProt Synonym Protein Names
Acylsphingosine deacylase; N-acylsphingosine amidohydrolase; Putative 32 kDa heart protein; PHP32
Protein Family
Acid ceramidase
UniProt Gene Name
ASAH1 [Similar Products]
UniProt Synonym Gene Names
ASAH; AC; ACDase; Acid CDase; PHP32 [Similar Products]
NCBI Summary for ASAH1
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
UniProt Comments for ASAH1
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
Research Articles on ASAH1
1. Acid ceramidase plays a critical role in acute myeloid leukemia cell survival via regulation of both sphingolipid levels and Mcl-1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
