Sarcosine, Conjugated, Polyclonal Antibody

Anti -Sarcosine, Conjugated

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 9; NC_000009.11 (136528682..136605077, complement). Location: 9q33-q34

Polyclonal

IgG

Rabbit

Recognizes protein-linked Sarcosine.

Purified
Purified by protein carrier (BSA) affinity column, and ammonium sulphate precipitation.

Supplied as a lyophilized powder. Reconstitute with 100ul sterile dH2O.

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 2 months at 4 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-SARDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Enzymes, Oxidase

Immunohistochemistry (IHC)

Suitable for use in Immunohistochemistry.

101,037 Da[Similar Products]

sarcosine dehydrogenase

sarcosine dehydrogenase, mitochondrial; dimethylglycine dehydrogenase-like 1

Sarcosine dehydrogenase, mitochondrial

DMGDHL1; SarDH  [Similar Products]

SARDH_HUMAN

This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]

SARDH: Defects in SARDH are a cause of sarcosinemia (SAR). Sarcosinemia is a metabolic disorder characterized by an increased concentration of sarcosine in plasma and urine due to sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1:28'000 to 1:350'000 in newborn screening programs. Sarcosinemia is most probably a benign condition without significant clinical problems. It is transmitted in an autosomal recessive manner. Belongs to the GcvT family.

Protein type: Mitochondrial; Oxidoreductase; EC 1.5.8.3; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: sarcosine dehydrogenase activity

Disease: Sarcosinemia

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