Full Product Name
Mouse monoclonal DMC1 antibody
Product Synonym Names
DMC1 antibody
Product Gene Name
anti-DMC1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14565
Species Reactivity
Human, Mouse, Bovine
Purity/Purification
Purified by affinity chromatography
Form/Format
Supplied as liquid in PBS with 0.02% sodium azide
Concentration
1 mg/ml (lot specific)
Immunogen
DMC1 antibody was raised in Mouse using human DMC1 protein (expressed as 6xHis fusion in E Coli and band cut out of gel of insoluble pelet) as the immunogen
Preparation and Storage
Store as concentrated solution. Aliquot and store at -20 degree C or below. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-DMC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-DMC1 antibody
DNA & RNA
Applications Tested/Suitable for anti-DMC1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DMC1. It may not necessarily be applicable to this product.
NCBI Accession #
CAG30372.1
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UniProt Primary Accession #
Q14565
[Other Products]
UniProt Secondary Accession #
Q08AI1; Q99498; Q9UH11; A8K9A2; B4DMW6[Other Products]
UniProt Related Accession #
Q14565[Other Products]
Molecular Weight
31,559 Da
NCBI Official Full Name
DMC1
NCBI Official Synonym Full Names
DNA meiotic recombinase 1
NCBI Official Symbol
DMC1 [Similar Products]
NCBI Official Synonym Symbols
DMC1H; LIM15; dJ199H16.1
[Similar Products]
NCBI Protein Information
meiotic recombination protein DMC1/LIM15 homolog
UniProt Protein Name
Meiotic recombination protein DMC1/LIM15 homolog
Protein Family
Meiotic recombination protein
UniProt Gene Name
DMC1 [Similar Products]
UniProt Synonym Gene Names
DMC1H; LIM15 [Similar Products]
NCBI Summary for DMC1
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Comments for DMC1
DMC1: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the RecA family. DMC1 subfamily.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA repair, damage
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: chromosome; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding
Biological Process: DNA recombinase assembly; female gamete generation; meiosis; mitotic recombination; response to ionizing radiation; spermatogenesis; strand invasion
Research Articles on DMC1
1. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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