Heparin Cofactor II, Polyclonal Antibody

Anti -Heparin Cofactor II (HCII)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 22; NC_000022.10 (21128383..21142008). Location: 22q11.2; 22q11.21

Polyclonal

IgG

Sheep

Human

Purified
Purified

-20 degree C

Small volumes of anti-SERPIND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Intended for use in the neutralization of HCII activity in clot-based assays. The recommended procedure is to mix 10ul of the neutralizing IgG with 90ul of plasma and allow to incubate at room temperature for 20 minutes before use. As a control for dilution and IgG addition, in a separate tube add 10ul of the control IgG to another 90ul of the same plasma and also incubate for 20 minutes. Both plasmas may then be used directly or placed on ice for up to 4 hours. These conditions are intended for neutralizing the inhibitory activity of HCII in the presence of dermatan sulfate (50ug/ml), providing HCII levels are within the normal range.

Antibodies; Abs to Coagulation Factors

Neutralization

57,071 Da[Similar Products]

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

heparin cofactor 2; serpin D1; leuserpin 2; OTTHUMP00000198450; OTTHUMP00000198451; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

Heparin cofactor 2

HCF2  [Similar Products]

HEP2_HUMAN

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq]

SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: chemotaxis; blood coagulation

Disease: Heparin Cofactor Ii Deficiency

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.