Product Name
SERPINA6, cDNA Clone
Full Product Name
SERPINA6 cDNA Clone
Product Gene Name
SERPINA6 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgccactcc tcctgtacac ctgtcttctc tggctgccca ccagcggcct ctggaccgtc caggccatgg atcctaacgc tgcttatgtg aacatgagta accatcaccg gggcctggct tcagccaacg ttgactttgc cttcagcctg tataagcacc tagtggcctt gagtcccaaa aagaacattt tcatctcccc tgtgagcatc tccatggcct tagctatgct gtccctgggc acctgtggcc acacacgggc ccagcttctc cagggcctgg gtttcaacct cactgagagg tctgagactg agatccacca gggtttccag cacctgcacc aactctttgc aaagtcagac accagcttag aaatgaccat gggcaatgcc ttgtttcttg atggcagcct ggagttgctg gagtcattct cagcagacat caagcactac tatgagtcag aggtcttggc tatgaatttc caggactggg caacagccag cagacagatc aacagctatg tcaagaataa gacacagggg aaaattgtcg acttgttttc agggctggat agcccagcca tcctcgtcct ggtcaactat atcttcttca aaggcacatg gacacagccc tttgacctgg caagcaccag ggaggagaac ttctatgtgg acgagacaac tgtggtgaag gtgcccatga tgttgcagtc gagcaccatc agttaccttc atgacgcgga gctcccctgc cagctggtgc agatgaacta cgtgggcaat gggactgtct tcttcatcct tccggacaag gggaagatga acacagtcat cgctgcactg agccgggaca cgattaacag gtggtccgca ggcctgacca gcagccaggt ggacctgtac attccaaagg tcaccatctc tggagtctat gacctcggag atgtgctgga ggaaatgggc attgcagact tgttcaccaa ccaggcaaat ttctcacgca tcacccagga cgcccagctg aagtcatcaa aggtggtcca taaagctgtg ctgcaactca atgaggaggg tgtggacaca gctggctcca ctggggtcac cctaaacctg acgtccaagc ctatcatctt gcgtttcaac cagcccttca tcatcatgat cttcgaccac ttcacctgga gcagcctttt cctggcgagg gttatgaacc cagtgtaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SERPINA6 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SERPINA6. It may not necessarily be applicable to this product.
NCBI Accession #
BC056259
[Other Products]
UniProt Secondary Accession #
Q7Z2Q9; A8K456[Other Products]
UniProt Related Accession #
P08185[Other Products]
Molecular Weight
45,141 Da
NCBI Official Full Name
Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, mRNA
NCBI Official Synonym Full Names
serpin family A member 6
NCBI Official Symbol
SERPINA6 [Similar Products]
NCBI Official Synonym Symbols
CBG
[Similar Products]
NCBI Protein Information
corticosteroid-binding globulin
UniProt Protein Name
Corticosteroid-binding globulin
UniProt Synonym Protein Names
Serpin A6; Transcortin
Protein Family
Serine protease inhibitor
UniProt Gene Name
SERPINA6 [Similar Products]
UniProt Synonym Gene Names
CBG; CBG [Similar Products]
UniProt Entry Name
CBG_HUMAN
NCBI Summary for SERPINA6
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINA6
SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding
Disease: Corticosteroid-binding Globulin Deficiency
Research Articles on SERPINA6
1. Human cardiomyocytes express mineralocorticoid receptors, but are mostly free of nuclear glucocorticoid receptors. CBG is expressed in myocardium and in Purkinje fibers. CBG in heart is colocalized with mineralocorticoid receptor.
Precautions
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Disclaimer
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