Product Name
Apoptosis regulatory protein Siva (SIVA1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Apoptosis regulatory protein Siva polyclonal Antibody(SIVA1), FITC
Product Synonym Names
CD27-binding protein; CD27BP; SIVA; SIVA1
Product Gene Name
anti-SIVA1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15304
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Apoptosis regulatory protein Siva protein(1-110aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7436 / sc-7250 / sc-48768 / sc-48768 / sc-48767
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SIVA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SIVA1 antibody
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Applications Tested/Suitable for anti-SIVA1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SIVA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006418.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006427.3
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UniProt Primary Accession #
O15304
[Other Products]
UniProt Secondary Accession #
Q96P98; Q9UPD6[Other Products]
UniProt Related Accession #
O15304[Other Products]
Molecular Weight
11,778 Da
NCBI Official Full Name
apoptosis regulatory protein Siva isoform 1
NCBI Official Synonym Full Names
SIVA1, apoptosis-inducing factor
NCBI Official Symbol
SIVA1 [Similar Products]
NCBI Official Synonym Symbols
SIVA; CD27BP; Siva-1; Siva-2
[Similar Products]
NCBI Protein Information
apoptosis regulatory protein Siva
UniProt Protein Name
Apoptosis regulatory protein Siva
UniProt Synonym Protein Names
CD27-binding protein; CD27BP
Protein Family
Apoptosis regulatory protein
UniProt Gene Name
SIVA1 [Similar Products]
UniProt Synonym Gene Names
SIVA; CD27BP [Similar Products]
UniProt Entry Name
SIVA_HUMAN
NCBI Summary for SIVA1
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for SIVA1
Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: cytoplasm; mitochondrion; nucleoplasm
Molecular Function: CD27 receptor binding; metal ion binding; protein binding; viral receptor activity; zinc ion binding
Biological Process: activated T cell apoptosis; entry of virus into host cell; inhibition of NF-kappaB transcription factor
Research Articles on SIVA1
1. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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