Product Name
PCCA, Protein Lysate
Full Product Name
PCCA Protein Lysate
Product Gene Name
PCCA protein lysate
[Similar Products]
Product Synonym Gene Name
PCCA[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P05165
Preparation and Storage
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of PCCA protein lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PCCA protein lysate
Partial length PCCA is expressed in E. coli.
Target Description: The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for PCCA protein lysate
Protein; Drugs and Drug Metabolism; Cell Biology;
NCBI/Uniprot data below describe general gene information for PCCA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000273
[Other Products]
NCBI GenBank Nucleotide #
NM_000282
[Other Products]
UniProt Primary Accession #
P05165
[Other Products]
UniProt Related Accession #
P05165[Other Products]
NCBI Official Full Name
propionyl-CoA carboxylase alpha chain, mitochondrial isoform a
NCBI Official Synonym Full Names
propionyl-CoA carboxylase subunit alpha
NCBI Official Symbol
PCCA [Similar Products]
NCBI Protein Information
propionyl-CoA carboxylase alpha chain, mitochondrial
UniProt Protein Name
Propionyl-CoA carboxylase alpha chain, mitochondrial
UniProt Synonym Protein Names
Propanoyl-CoA:carbon dioxide ligase subunit alpha
UniProt Gene Name
PCCA [Similar Products]
UniProt Synonym Gene Names
PCCase subunit alpha [Similar Products]
UniProt Entry Name
PCCA_HUMAN
NCBI Summary for PCCA
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Research Articles on PCCA
1. The data indicate that amino acid/nucleotide metabolism-related genes OGDH, PPAT and PCCA acquire somatic mutations in microsatellite instability-high gastric cancers and colorectal cancers and that mutational intratumoral heterogeneity may occur in at least some of these tumors.
Precautions
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Disclaimer
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