Product Name
ADH5 (ADH5 (HGNC:253)), Blocking Peptide
Product Synonym Names
Alcohol dehydrogenase class-3; Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; 111-; S-(hydroxymethyl)glutathione dehydrogenase; ADH5
Product Gene Name
ADH5 (HGNC:253) blocking peptide
[Similar Products]
Product Synonym Gene Name
ADHX; FDH[Similar Products]
Antibody/Peptide Pairs
ADH5 peptide (MBS9227704) is used for blocking the activity of ADH5 antibody (MBS9213870)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11766
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human ADH5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ADH5 (HGNC:253) blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ADH5 (HGNC:253) blocking peptide
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
NCBI/Uniprot data below describe general gene information for ADH5 (HGNC:253). It may not necessarily be applicable to this product.
NCBI Accession #
P11766.4
[Other Products]
UniProt Primary Accession #
P11766
[Other Products]
UniProt Secondary Accession #
Q6FHR2[Other Products]
UniProt Related Accession #
P11766[Other Products]
Molecular Weight
39,724 Da
NCBI Official Full Name
Alcohol dehydrogenase class-3
NCBI Official Synonym Full Names
alcohol dehydrogenase 5 (class III), chi polypeptide
NCBI Official Symbol
ADH5 [Similar Products]
NCBI Official Synonym Symbols
FDH; ADHX; ADH-3; FALDH; GSNOR; GSH-FDH; HEL-S-60p
[Similar Products]
NCBI Protein Information
alcohol dehydrogenase class-3
UniProt Protein Name
Alcohol dehydrogenase class-3
UniProt Synonym Protein Names
Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-); FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284)
UniProt Gene Name
ADH5 [Similar Products]
UniProt Synonym Gene Names
FALDH; FDH; GSH-FDH [Similar Products]
UniProt Entry Name
ADHX_HUMAN
NCBI Summary for ADH5 (HGNC:253)
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ADH5 (HGNC:253)
ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein type: Lipid Metabolism - fatty acid; Energy Metabolism - methane; EC 1.1.1.284; Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.1; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: cytosol
Molecular Function: electron carrier activity; fatty acid binding; formaldehyde dehydrogenase activity; S-(hydroxymethyl)glutathione dehydrogenase activity; zinc ion binding
Biological Process: ethanol oxidation; response to redox state
Research Articles on ADH5 (HGNC:253)
1. ADH5 counteracts neuronal differentiation of neural stem cells and this effect can be reversed by pharmacological inhibition of ADH5.
Precautions
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Disclaimer
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