Product Synonym Names
EDS6; LH; LH1; LLH; PLOD
Product Gene Name
anti-PLOD1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q02809
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human PLOD1
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PLOD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PLOD1 antibody
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-PLOD1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PLOD1 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for PLOD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000293.2
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NCBI GenBank Nucleotide #
NM_000302.3
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UniProt Primary Accession #
Q02809
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UniProt Secondary Accession #
Q96AV9; Q9H132; B4DR87[Other Products]
UniProt Related Accession #
Q02809[Other Products]
NCBI Official Full Name
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2
NCBI Official Synonym Full Names
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
NCBI Official Symbol
PLOD1 [Similar Products]
NCBI Official Synonym Symbols
LH; LH1; LLH; EDS6; PLOD; EDSKCL1
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NCBI Protein Information
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
UniProt Protein Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
UniProt Synonym Protein Names
Lysyl hydroxylase 1; LH1
Protein Family
Procollagen-lysine,2-oxoglutarate 5-dioxygenase
UniProt Gene Name
PLOD1 [Similar Products]
UniProt Synonym Gene Names
LLH; PLOD; LH1 [Similar Products]
NCBI Summary for PLOD1
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
UniProt Comments for PLOD1
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable).
Research Articles on PLOD1
1. Ehlers Danlos syndrome in two children was confirmed by mutations in PLOD1 gene. Initially patients were thought to have either a diagnosis of classical EDS (cEDS) or a neuromuscular disorder due to absence of (congenital) scoliosis.
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