Product Name
RARS2, Polyclonal Antibody
Popular Item
Full Product Name
RARS2 Polyclonal Antibody
Product Gene Name
anti-RARS2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5T160
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human RARS2
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-RARS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RARS2 antibody
The protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6).
Applications Tested/Suitable for anti-RARS2 antibody
Western Blot (WB)
Application Notes for anti-RARS2 antibody
WB 1:500 - 1:2000
Western Blot (WB) of anti-RARS2 antibody
Western blot analysis of extracts of various cell lines, using RARS2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
Immunohistochemistry (IHC) of anti-RARS2 antibody
Immunohistochemistry of paraffin-embedded mouse stomach using RARS2 antibody at dilution of 1:100 (40x lens).
NCBI/Uniprot data below describe general gene information for RARS2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064716.2
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NCBI GenBank Nucleotide #
NM_020320.3
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UniProt Primary Accession #
Q5T160
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UniProt Secondary Accession #
Q96FU5; Q9H8K8; B2RDT7[Other Products]
UniProt Related Accession #
Q5T160[Other Products]
NCBI Official Full Name
probable arginine--tRNA ligase, mitochondrial
NCBI Official Synonym Full Names
arginyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
RARS2 [Similar Products]
NCBI Official Synonym Symbols
PCH6; ArgRS; RARSL; DALRD2; PRO1992; dJ382I10.6
[Similar Products]
NCBI Protein Information
probable arginine--tRNA ligase, mitochondrial
UniProt Protein Name
Probable arginine--tRNA ligase, mitochondrial
UniProt Synonym Protein Names
Arginyl-tRNA synthetase; ArgRS
Protein Family
Probable arginine--tRNA ligase
UniProt Gene Name
RARS2 [Similar Products]
UniProt Synonym Gene Names
RARSL; ArgRS [Similar Products]
UniProt Entry Name
SYRM_HUMAN
NCBI Summary for RARS2
The protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). [provided by RefSeq, Oct 2008]
UniProt Comments for RARS2
RARS2: Defects in RARS2 are the cause of pontocerebellar hypoplasia type 6 (PCH6); also known as fatal infantile encephalopathy with mitochondrial respiratory chain defects. Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: EC 6.1.1.19; Mitochondrial; Ligase
Chromosomal Location of Human Ortholog: 6q16.1
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: arginine-tRNA ligase activity; ATP binding
Biological Process: arginyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; mitochondrial translation; gene expression
Disease: Pontocerebellar Hypoplasia, Type 6
Research Articles on RARS2
1. G/p.I9V and the c.1586+3A>T in family A.">Molecular investigations of RARS2 disclosed the c.25A>G/p.I9V and the c.1586+3A>T in family A.
Precautions
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Disclaimer
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