Product Name
RARS2, Blocking Peptide
Full Product Name
RARS2 Blocking Peptide (C-term)
Product Synonym Names
Probable arginine--tRNA ligase; mitochondrial; Arginyl-tRNA synthetase; ArgRS; RARS2; RARSL
Product Gene Name
RARS2 blocking peptide
[Similar Products]
Product Synonym Gene Name
RARSL[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5T160
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human RARS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder.
Reconstitution
Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion matrix.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of RARS2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for RARS2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064716.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020320.4
[Other Products]
UniProt Primary Accession #
Q5T160
[Other Products]
UniProt Secondary Accession #
Q96FU5; Q9H8K8; B2RDT7[Other Products]
UniProt Related Accession #
Q5T160[Other Products]
Molecular Weight
65,505 Da
NCBI Official Full Name
probable arginine--tRNA ligase, mitochondrial isoform 1
NCBI Official Synonym Full Names
arginyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
RARS2 [Similar Products]
NCBI Official Synonym Symbols
PCH6; ArgRS; RARSL; DALRD2; PRO1992
[Similar Products]
NCBI Protein Information
probable arginine--tRNA ligase, mitochondrial
UniProt Protein Name
Probable arginine--tRNA ligase, mitochondrial
UniProt Synonym Protein Names
Arginyl-tRNA synthetase; ArgRS
Protein Family
Probable arginine--tRNA ligase
UniProt Gene Name
RARS2 [Similar Products]
UniProt Synonym Gene Names
RARSL; ArgRS [Similar Products]
NCBI Summary for RARS2
This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for RARS2
RARS2: Defects in RARS2 are the cause of pontocerebellar hypoplasia type 6 (PCH6); also known as fatal infantile encephalopathy with mitochondrial respiratory chain defects. Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: EC 6.1.1.19; Ligase; Mitochondrial
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: arginine-tRNA ligase activity
Biological Process: arginyl-tRNA aminoacylation; mitochondrial translation; tRNA aminoacylation for protein translation
Disease: Pontocerebellar Hypoplasia, Type 6
Research Articles on RARS2
1. RARS2 gene mutations can cause a metabolic neurodegenerative disease manifesting primarily as early onset epileptic encephalopathies with post-natal microcephaly, without pontocerebellar hypoplasia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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