transmembrane inner ear, ELISA Kit

Human Transmembrane inner ear expressed protein (TMIE) ELISA kit; DFNB6; transmembrane inner ear protein; transmembrane inner ear

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TMIE elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9326813 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the transmembrane inner ear (TMIE) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TMIE. The ELISA analytical biochemical technique of the MBS9326813 kit is based on TMIE antibody-TMIE antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TMIE antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TMIE. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

17,241 Da

transmembrane inner ear

transmembrane inner ear expressed protein; transmembrane inner ear protein

Transmembrane inner ear expressed protein

TMIE_HUMAN

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]

TMIE: Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Defects in TMIE are the cause of deafness autosomal recessive type 6 (DFNB6). DFNB6 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to membrane

Biological Process: inner ear morphogenesis; sensory perception of sound

Disease: Deafness, Autosomal Recessive 6

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