CD247, Monoclonal Antibody

T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; CD247

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

4B10

Mouse

Ascitic fluid containing 0.03% sodium azide.

Small volumes of anti-CD247 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Entrez Summary: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Western blot analysis using CD247 mAb against CD247 (AA

Immunofluorescence analysis of K562 cells using anti-CD247 mAb (green). Blue

Flow cytometric analysis of Jurkat cells using anti-CD247 mAb (green) and negative control (purple).

Immunohistochemical analysis of paraffin-embedded human Thymus tissues using anti-CD247 mouse mAb

18

CD247 molecule

T-cell surface glycoprotein CD3 zeta chain

T-cell surface glycoprotein CD3 zeta chain

CD3Z; T3Z; TCRZ  [Similar Products]

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: cytoplasm; plasma membrane; T cell receptor complex

Molecular Function: identical protein binding; protein binding

Biological Process: regulation of defense response to virus by virus; regulation of immune response; T cell costimulation; T cell receptor signaling pathway

Disease: Immunodeficiency 25

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