Full Product Name
CD247 Antibody
Product Synonym Names
CD3-ZETA; CD3H; CD3Q; CD3Z; T3Z; TCRZ
Product Gene Name
anti-CD247 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of CD247
Calculated Molecular Weight: 16kd
Observed Molecular Weight: 16kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1124 / sc-20919
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD247 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CD247 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CD247 antibody
WB: 1:500-1:5000
IHC: 1:50-1:200
Testing Data of anti-CD247 antibody
NCBI/Uniprot data below describe general gene information for CD247. It may not necessarily be applicable to this product.
NCBI Accession #
ABW06579.1
[Other Products]
UniProt Secondary Accession #
Q5VX13; Q8TAX4; B1AK49[Other Products]
UniProt Related Accession #
P20963; A46461[Other Products]
NCBI Official Full Name
CD247, partial
NCBI Official Synonym Full Names
CD247 molecule
NCBI Official Symbol
CD247 [Similar Products]
NCBI Official Synonym Symbols
T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3-ZETA
[Similar Products]
NCBI Protein Information
T-cell surface glycoprotein CD3 zeta chain; CD247 antigen, zeta subunit; CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 zeta chain; TCR zeta chain
UniProt Protein Name
T-cell surface glycoprotein CD3 zeta chain
UniProt Synonym Protein Names
T-cell receptor T3 zeta chain; CD_antigen: CD247
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD247 [Similar Products]
UniProt Synonym Gene Names
CD3Z; T3Z; TCRZ [Similar Products]
UniProt Entry Name
CD3Z_HUMAN
NCBI Summary for CD247
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CD247
CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component: T cell receptor complex; cytoplasm; integral to membrane; plasma membrane; alpha-beta T cell receptor complex
Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; protein homodimerization activity
Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus
Disease: Immunodeficiency 25
Research Articles on CD247
1. Myeloid-derived suppressor cell frequency in peripheral blood is directly correlated with the HCV RNA load in the plasma and inversely correlated with TCR zeta chain expression in CD8(+) T cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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