Full Product Name
Human A2M Polyclonal Antibody
Product Synonym Names
FWP007; CPAMD5; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Product Gene Name
anti-A2M antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01023
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human A2M Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-A2M antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NP_000005.2
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UniProt Primary Accession #
P01023
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UniProt Related Accession #
P01023[Other Products]
NCBI Official Full Name
alpha-2-macroglobulin isoform a
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
A2M [Similar Products]
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
NCBI Protein Information
alpha-2-macroglobulin
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
Alpha-2-macroglobulin
UniProt Gene Name
A2M [Similar Products]
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M [Similar Products]
UniProt Entry Name
A2MG_HUMAN
NCBI Summary for A2M
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
UniProt Comments for A2M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.
Protein type: Secreted, signal peptide; Inhibitor; Secreted
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: extracellular region; cytosol
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding
Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway
Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
Research Articles on A2M
1. Impaired fibrinolysis and lower levels of alpha2-macroglobulin might predispose to a higher rate of asthma exacerbations, suggesting new links between disturbed hemostasis and asthma.
Precautions
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Disclaimer
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