Full Product Name
A2M Antibody
Product Synonym Names
CPAMD5; DKFZp779B086; FWP007; S863-7; A2MD
Product Gene Name
anti-A2M antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
A synthetic peptide of human A2M
Observed Molecular Weight: 163kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-A2M antibody
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
Applications Tested/Suitable for anti-A2M antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-A2M antibody
Western blot analysis of extracts of various cell lines, using A2M antibody.
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
NCBI Accession #
AAH26246.1
[Other Products]
UniProt Secondary Accession #
Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97[Other Products]
UniProt Related Accession #
P01023[Other Products]
Molecular Weight
163,291 Da
NCBI Official Full Name
A2M protein
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
A2M [Similar Products]
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
NCBI Protein Information
alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
Alpha-2-macroglobulin
UniProt Gene Name
A2M [Similar Products]
UniProt Synonym Gene Names
CPAMD5; Alpha-2-M [Similar Products]
UniProt Entry Name
A2MG_HUMAN
NCBI Summary for A2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
UniProt Comments for A2M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.
Protein type: Secreted; Inhibitor; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: extracellular region; cytosol
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-8 binding; interleukin-1 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding
Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; regulation of small GTPase mediated signal transduction; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway
Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
Research Articles on A2M
1. phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
