Full Product Name
AIM2 Antibody
Product Synonym Names
Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2
Product Gene Name
anti-AIM2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14862
Specificity
AIM2 antibody detects endogenous levels of total AIM2 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human AIM2.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-AIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-AIM2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AIM2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AIM2 antibody
WB: 1:500~1:1000
ELISA: 1:40000
Western Blot (WB) of anti-AIM2 antibody
Western blot analysis of extracts from HUVEC cells, using AIM2 antibody.
NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004824.1
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NCBI GenBank Nucleotide #
NM_004833.2
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UniProt Primary Accession #
O14862
[Other Products]
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7[Other Products]
UniProt Related Accession #
O14862[Other Products]
Molecular Weight
38,954 Da
NCBI Official Full Name
interferon-inducible protein AIM2 isoform 1
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2 [Similar Products]
NCBI Official Synonym Symbols
PYHIN4
[Similar Products]
NCBI Protein Information
interferon-inducible protein AIM2
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
UniProt Gene Name
AIM2 [Similar Products]
NCBI Summary for AIM2
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
UniProt Comments for AIM2
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Product References and Citations for anti-AIM2 antibody
DeYoung K.L., Oncogene 15:453-457(1997). Gregory S.G., Nature 441:315-321(2006).
Research Articles on AIM2
1. These results provide evidence for the role of AIM2 in the progression of cSCC and identify AIM2 inflammasome function as a potential therapeutic target in these invasive and metastatic tumors.
Precautions
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Disclaimer
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