Full Product Name
AIM2 Antibody
Product Gene Name
anti-AIM2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14862
Form/Format
Purified by protein A column containing 0.02% NaN3
Reconstitution
Reconstitute in 200ul sterile H2O.
Preparation and Storage
The Lyophilized antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-AIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AIM2 antibody
Rabbit polyclonal AIM2 (1) antibody was raised against a recombinate human AIM2 protein 93-341aa (NM_004833).
Product Categories/Family for anti-AIM2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-AIM2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AIM2 antibody
ELISA: 1:10,000-1:80,000
WB: 1:200-1:1,000
IHC: 1:50-200
Testing Data of anti-AIM2 antibody
Testing Data of anti-AIM2 antibody
NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004824.1
[Other Products]
NCBI GenBank Nucleotide #
NM_004833
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UniProt Primary Accession #
O14862
[Other Products]
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7[Other Products]
UniProt Related Accession #
O14862[Other Products]
Molecular Weight
38,954 Da
NCBI Official Full Name
interferon-inducible protein AIM2 isoform 1
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2 [Similar Products]
NCBI Official Synonym Symbols
PYHIN4
[Similar Products]
NCBI Protein Information
interferon-inducible protein AIM2
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
UniProt Gene Name
AIM2 [Similar Products]
NCBI Summary for AIM2
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
UniProt Comments for AIM2
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Product References and Citations for anti-AIM2 antibody
(1) Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J. and Alnemri, E.S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.Nature 458 (7237), 509-513 (2009).
Research Articles on AIM2
1. These results provide evidence for the role of AIM2 in the progression of cSCC and identify AIM2 inflammasome function as a potential therapeutic target in these invasive and metastatic tumors.
Precautions
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Disclaimer
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