KCNA5/Kv1.5, Polyclonal Antibody

Rabbit Polyclonal (IgG) to Mouse KCNA5/Kv1.5; KCNA5; Cardiac potassium channel; HCK1; HPCN1; HuK6; HuKVI; RMK2; PCN1; RK3; ATFB7; KV1.5; Potassium channel 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human 67 kD protein

Antiserum

Lyophilized antiserum

Short term: 4 degree C
Long term: -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-KCNA5/Kv1.5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Potassium channels represent the most complex class of voltage-gatedino channels from both functional and structural standpoints. their diverse functions include regulating neurotransmitter release, heartrate, insulin secretion, neuronal excitability, epithelial electrolytetransport, smooth muscle contraction, and cell volume. Foursequence-related potassium channel genes - shaker, shaw, shab, and shal -have been identified in Drosophila, and each has been shown to havehuman homolog(s).

Ion Channel; Potassium channel - Kv1 Shaker

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 10 ug/ml
WB: 1:1000-1:5000

Anti-KCNA5/Kv1.5 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

44,427 Da

potassium voltage-gated channel subfamily A member 5

potassium voltage-gated channel subfamily A member 5

Potassium voltage-gated channel subfamily A member 5

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).

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