Kv1.5, Blocking Peptide

Potassium voltage-gated channel subfamily A member 5; HPCN1; Voltage-gated potassium channel HK2; Voltage-gated potassium channel subunit Kv1.5

For Research Use Only. Not for use in diagnostic procedures.

Synthetic

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Small volumes of KCNA5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The peptide is used to block Anti-Kv1.5 Antibody reactivity.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

44,427 Da

potassium voltage-gated channel, shaker-related subfamily, member 5

potassium voltage-gated channel subfamily A member 5; potassium channel 1; cardiac potassium channel; voltage-gated potassium channel HK2; insulinoma and islet potassium channel; voltage-gated potassium channel protein Kv1.5; voltage-gated potassium channel subunit Kv1.5

Potassium voltage-gated channel subfamily A member 5

KCNA5_HUMAN

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; intracellular canaliculus; integral to plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; caveola; Z disc; lipid raft

Molecular Function: protein binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; alpha-actinin binding; potassium channel inhibitor activity; protein kinase binding; receptor binding

Biological Process: synaptic transmission; regulation of membrane potential; regulation of potassium ion transport; negative regulation of potassium ion transport; reduction of cytosolic calcium ion concentration; regulation of vasoconstriction; membrane hyperpolarization; response to hypoxia; regulation of insulin secretion; potassium ion homeostasis; potassium ion transport; protein homooligomerization

Disease: Atrial Fibrillation, Familial, 7

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