Product Name
P2RY12, cDNA Clone
Popular Item
Full Product Name
P2RY12 cDNA Clone
Product Gene Name
P2RY12 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcaagccg tcgacaatct cacctctgcg cctgggaaca ccagtctgtg caccagagac tacaaaatca cccaggtcct cttcccactg ctctacactg tcctgttttt tgttggactt atcacaaatg gcctggcgat gaggattttc tttcaaatcc ggagtaaatc aaactttatt atttttctta agaacacagt catttctgat cttctcatga ttctgacttt tccattcaaa attcttagtg atgccaaact gggaacagga ccactgagaa cttttgtgtg tcaagttacc tccgtcatat tttatttcac aatgtatatc agtatttcat tcctgggact gataactatc gatcgctacc agaagaccac caggccattt aaaacatcca accccaaaaa tctcttgggg gctaagattc tctctgttgt catctgggca ttcatgttct tactctcttt gcctaacatg attctgacca acaggcagcc gagagacaag aatgtgaaga aatgctcttt ccttaaatca gagttcggtc tagtctggca tgaaatagta aattacatct gtcaagtcat tttctggatt aatttcttaa ttgttattgt atgttataca ctcattacaa aagaactgta ccggtcatac gtaagaacga ggggtgtagg taaagtcccc aggaaaaagg tgaacgtcaa agttttcatt atcattgctg tattctttat ttgttttgtt cctttccatt ttgcccgaat tccttacacc ctgagccaaa cccgggatgt ctttgactgc actgctgaaa atactctgtt ctatgtgaaa gagagcactc tgtggttaac ttccttaaat gcatgcctgg atccgttcat ctattttttc ctttgcaagt ccttcagaaa ttccttgata agtatgctga agtgccccaa ttctgcaaca tctctgtccc aggacaatag gaaaaaagaa caggatggtg gtgacccaaa tgaagagact ccaatgtaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of P2RY12 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for P2RY12. It may not necessarily be applicable to this product.
NCBI Accession #
BC017898
[Other Products]
UniProt Secondary Accession #
Q546J7; D3DNJ5[Other Products]
UniProt Related Accession #
Q9H244[Other Products]
Molecular Weight
39,439 Da
NCBI Official Full Name
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12, mRNA
NCBI Official Synonym Full Names
purinergic receptor P2Y12
NCBI Official Symbol
P2RY12 [Similar Products]
NCBI Official Synonym Symbols
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
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NCBI Protein Information
P2Y purinoceptor 12
UniProt Protein Name
P2Y purinoceptor 12
UniProt Synonym Protein Names
ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
Protein Family
P2Y purinoceptor
UniProt Gene Name
P2RY12 [Similar Products]
UniProt Synonym Gene Names
HORK3; P2Y12; ADPG-R; P2Y(ADP) [Similar Products]
UniProt Entry Name
P2Y12_HUMAN
NCBI Summary for P2RY12
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Comments for P2RY12
P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Mitochondrial; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: cell surface; integral to plasma membrane; intrinsic to membrane; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; platelet ADP receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; substrate-bound cell migration, cell extension
Disease: Bleeding Disorder, Platelet-type, 8
Research Articles on P2RY12
1. Baseline platelet aggregation was increased in carriers of the common alleles of P2Y12 SNPs rs1907637, rs2046934, and rs6809699 and rs6787801 TC heterozygotes.
Precautions
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Disclaimer
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