Full Product Name
GHR Antibody, Biotin conjugated
Product Synonym Names
Growth hormone receptor; GH receptor; Somatotropin receptor; Growth hormone-binding protein; GH-binding protein; GHBP; Serum-binding protein; GHR
Product Gene Name
anti-GHR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10912
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Growth hormone receptor protein (19-184AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GHR antibody
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).
Product Categories/Family for anti-GHR antibody
Cell
biology; Developmental biology; Signal transduction
Applications Tested/Suitable for anti-GHR antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for GHR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000154.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000163.4
[Other Products]
UniProt Primary Accession #
P10912
[Other Products]
UniProt Secondary Accession #
Q9HCX2[Other Products]
UniProt Related Accession #
P10912[Other Products]
Molecular Weight
69,237 Da
NCBI Official Full Name
growth hormone receptor isoform 1
NCBI Official Synonym Full Names
growth hormone receptor
NCBI Official Symbol
GHR [Similar Products]
NCBI Official Synonym Symbols
GHBP; GHIP
[Similar Products]
NCBI Protein Information
growth hormone receptor
UniProt Protein Name
Growth hormone receptor
UniProt Synonym Protein Names
Somatotropin receptor
UniProt Gene Name
GHR [Similar Products]
UniProt Synonym Gene Names
GH receptor; GH-binding protein; GHBP [Similar Products]
NCBI Summary for GHR
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
UniProt Comments for GHR
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway ().
Research Articles on GHR
1. The results suggest that both of the possible single mutation-containing heteromeric GH-GHR complexes, as well as the double GHR mutant complex result in perturbation of complex structures, with altered ability of the GHR dimers to interact with the GH peptide.
Precautions
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Disclaimer
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