Product Name
FANCB, Blocking Peptide
Full Product Name
FANCB Antibody (Center) Blocking Peptide
Product Synonym Names
Fanconi anemia group B protein; Protein FACB; Fanconi anemia-associated polypeptide of 95 kDa; FAAP95; FANCB
Product Gene Name
FANCB blocking peptide
[Similar Products]
Antibody/Peptide Pairs
FANCB peptide (MBS9223073) is used for blocking the activity of FANCB antibody (MBS9202534)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NB91
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Nucleus.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of FANCB blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FANCB blocking peptide
DNA repair protein required for FANCD2 ubiquitination.
NCBI/Uniprot data below describe general gene information for FANCB. It may not necessarily be applicable to this product.
NCBI Accession #
Q8NB91.1
[Other Products]
UniProt Primary Accession #
Q8NB91
[Other Products]
UniProt Secondary Accession #
Q7Z2U2; Q86XG1; B2RMZ4[Other Products]
UniProt Related Accession #
Q8NB91[Other Products]
Molecular Weight
97,726 Da
NCBI Official Full Name
Fanconi anemia group B protein
NCBI Official Synonym Full Names
Fanconi anemia complementation group B
NCBI Official Symbol
FANCB [Similar Products]
NCBI Official Synonym Symbols
FA2; FAB; FACB; FAAP90; FAAP95
[Similar Products]
NCBI Protein Information
Fanconi anemia group B protein
UniProt Protein Name
Fanconi anemia group B protein
UniProt Synonym Protein Names
Fanconi anemia-associated polypeptide of 95 kDa; FAAP95
Protein Family
Fanconi anemia group B protein
UniProt Gene Name
FANCB [Similar Products]
UniProt Synonym Gene Names
Protein FACB; FAAP95 [Similar Products]
UniProt Entry Name
FANCB_HUMAN
NCBI Summary for FANCB
This gene encodes a member of the Fanconi anemia complementation group B. This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions. Mutations in this gene can cause chromosome instability and VACTERL syndrome with hydrocephalus. [provided by RefSeq, Apr 2016]
UniProt Comments for FANCB
FANCB: DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB). It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some severe FANCB cases manifest features of VACTERL syndrome with hydrocephalus.
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: nucleoplasm
Molecular Function: protein binding
Disease: Fanconi Anemia, Complementation Group B; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Vacterl Association, X-linked, With Or Without Hydrocephalus
Research Articles on FANCB
1. Loss-of-function FANCB mutations result in a recognizable, multiple malformation phenotype in hemizygous males for which we propose clinical criteria to aid diagnosis.
Precautions
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Disclaimer
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