Product Name
hCG_1745121 (ISPD), Polyclonal Antibody
Full Product Name
hCG_1745121 Antibody (C-term)
Product Synonym Names
Isoprenoid synthase domain-containing protein; 277-; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; ISPD
Product Gene Name
anti-ISPD antibody
[Similar Products]
Antibody/Peptide Pairs
hCG_1745121 peptide (MBS9225863) is used for blocking the activity of hCG_1745121 antibody (MBS9201095)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
400-429
3D Structure
ModBase 3D Structure for A4D126
Species Reactivity
Human, mouse
Specificity
This hCG_1745121 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the C-terminal region of human hCG_1745121.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ISPD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ISPD antibody
Cell Biology
Applications Tested/Suitable for anti-ISPD antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ISPD antibody
WB~~1:1000
Western Blot (WB) of anti-ISPD antibody
hCG_1745121 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CG_1745121 antibody detected CG_1745121 protein (arrow).
NCBI/Uniprot data below describe general gene information for ISPD. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001094887.1
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NCBI Related Accession #
Human, mouseNP_001094896.1[Other Products]
NCBI GenBank Nucleotide #
NM_001101417.3
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UniProt Primary Accession #
A4D126
[Other Products]
UniProt Secondary Accession #
A8MU35; H9KVB2[Other Products]
UniProt Related Accession #
A4D126[Other Products]
NCBI Official Full Name
isoprenoid synthase domain-containing protein isoform b
NCBI Official Synonym Full Names
isoprenoid synthase domain containing
NCBI Official Symbol
ISPD [Similar Products]
NCBI Official Synonym Symbols
Nip; MDDGA7; MDDGC7; hCG_1745121
[Similar Products]
NCBI Protein Information
isoprenoid synthase domain-containing protein
UniProt Protein Name
Isoprenoid synthase domain-containing protein
UniProt Synonym Protein Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein
Protein Family
Isoprenoid synthase domain-containing protein
UniProt Gene Name
ISPD [Similar Products]
UniProt Entry Name
ISPD_HUMAN
NCBI Summary for ISPD
This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
UniProt Comments for ISPD
ISPD: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation. Defects in ISPD are the cause of muscular dystrophy- dystroglycanopathy congenital with brain and eye anomalies type A7 (MDDGA7). MDDGA7 is an autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye- brain disease. Belongs to the IspD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.7.-; Transferase
Chromosomal Location of Human Ortholog: 7p21.2
Molecular Function: nucleotidyltransferase activity
Biological Process: axon guidance; isoprenoid biosynthetic process; protein amino acid O-linked mannosylation
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 7; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 7
Research Articles on ISPD
1. study report the involvement of the ISPD gene in milder dystroglycanopathy phenotypes ranging from congenital muscular dystrophy to limb-girdle muscular dystrophy and identified allelic ISPD variants in nine cases belonging to seven families
Precautions
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