Product Name
GNAT2, Polyclonal Antibody
Popular Item
Full Product Name
GNAT2 Antibody
Product Synonym Names
ACHM4; Cone type transducin alpha subunit; GNAT 2; GNAT C; Gnat2; GNAT2_HUMAN; GNATC; Guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 2; Guanine nucleotide binding protein G t subunit alpha 2; Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha 2; Transducin alpha-2 chain; Transducin alpha2; Transducin cone specific alpha polypeptide
Product Gene Name
anti-GNAT2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P19087
Species Reactivity
Human, Mouse
Specificity
GNAT2 antibody detects endogenous levels of total GNAT2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide
Tissue Specificity
Retinal rod outer segment.
Predicted Cross Reactivity
Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Similarity
Zebrafish (91%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-GNAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNAT2 antibody
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Subunit Structure: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide .
Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Applications Tested/Suitable for anti-GNAT2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-GNAT2 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500
Immunofluorescence (IF) of anti-GNAT2 antibody
MBS9605565 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.

Western Blot (WB) of anti-GNAT2 antibody
Western blot analysis of extracts from COLO cells, using GNAT2 antibody.

NCBI/Uniprot data below describe general gene information for GNAT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005263.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005272.3
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UniProt Primary Accession #
P19087
[Other Products]
UniProt Related Accession #
P19087[Other Products]
Molecular Weight
Observed: 40 kD
Predicted: 41 kDa
NCBI Official Full Name
guanine nucleotide-binding protein G(t) subunit alpha-2
NCBI Official Synonym Full Names
G protein subunit alpha transducin 2
NCBI Official Symbol
GNAT2 [Similar Products]
NCBI Official Synonym Symbols
ACHM4; GNATC
[Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Protein Name
Guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Synonym Protein Names
Transducin alpha-2 chain
UniProt Gene Name
GNAT2 [Similar Products]
UniProt Synonym Gene Names
GNATC [Similar Products]
NCBI Summary for GNAT2
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
UniProt Comments for GNAT2
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Research Articles on GNAT2
1. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).
Precautions
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Disclaimer
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