Full Product Name
GNAT2 Antibody - middle region
Product Gene Name
anti-GNAT2 antibody
[Similar Products]
Product Synonym Gene Name
ACHM4; GNATC[Similar Products]
Antibody/Peptide Pairs
GNAT2 peptide (MBS3246470) is used for blocking the activity of GNAT2 antibody (MBS3221744)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: FPEYDGNNSY DDAGNYIKSQ FLDLNMRKDV KEIYSHMTCA TDTQNVKFVF
3D Structure
ModBase 3D Structure for P19087
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human GNAT2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GNAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNAT2 antibody
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Product Categories/Family for anti-GNAT2 antibody
Polyclonal; RNA Binding Proteins; Signal Transduction;
Applications Tested/Suitable for anti-GNAT2 antibody
Western Blot (WB)
Western Blot (WB) of anti-GNAT2 antibody
Host: Rabbit
Target Name: GNAT2
Sample Tissue: Human HCT116 Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for GNAT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005263.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005272.3
[Other Products]
UniProt Primary Accession #
P19087
[Other Products]
UniProt Related Accession #
P19087[Other Products]
NCBI Official Full Name
guanine nucleotide-binding protein G(t) subunit alpha-2
NCBI Official Synonym Full Names
G protein subunit alpha transducin 2
NCBI Official Symbol
GNAT2 [Similar Products]
NCBI Official Synonym Symbols
ACHM4; GNATC
[Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Protein Name
Guanine nucleotide-binding protein G(t) subunit alpha-2
UniProt Synonym Protein Names
Transducin alpha-2 chain
UniProt Gene Name
GNAT2 [Similar Products]
UniProt Synonym Gene Names
GNATC [Similar Products]
UniProt Entry Name
GNAT2_HUMAN
NCBI Summary for GNAT2
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
UniProt Comments for GNAT2
G-alpha t2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4). Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination. Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein type: G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: photoreceptor outer segment; photoreceptor inner segment; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; GTP binding; G-protein-coupled receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; G-protein coupled photoreceptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; visual perception; retinal cone cell development; metabolic process; response to light intensity; phototransduction; detection of light stimulus involved in visual perception; detection of chemical stimulus involved in sensory perception of bitter taste
Disease: Achromatopsia 4
Research Articles on GNAT2
1. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R).
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