PDE6H, Polyclonal Antibody

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma; PDE6H

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.36 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PDE6H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes the inhibitory (or gamma) subunit of the
cone-specific cGMP phosphodiesterase, which is a tetramer composed
of two catalytic chains (alpha and beta), and two inhibitory chains
(gamma). It is specifically expressed in the retina, and is
involved in the transmission and amplification of the visual
signal. Mutations in this gene are associated with retinal cone
dystrophy type 3A (RCD3A).

Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

PDE6H Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the PDE6H antibody detected the PDE6H protein (arrow).

9074

phosphodiesterase 6H, cGMP-specific, cone, gamma

retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

GMP-PDE gamma  [Similar Products]

CNCG_HUMAN

This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]

PDE6H: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Defects in PDE6H are the cause of cone dystrophy retinal type 3A (RCD3A); also known as cone dystrophy with night blindness and supernormal rod responses. RCD3A is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the rod/cone cGMP-PDE gamma subunit family.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.35; Inhibitor

Chromosomal Location of Human Ortholog: 12p13

Molecular Function: enzyme inhibitor activity; 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding

Biological Process: visual perception; activation of MAPK activity; metabolic process; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; negative regulation of catalytic activity; response to stimulus

Disease: Retinal Cone Dystrophy 3a

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Piri, N., et al. Ophthalmology 112(1):159-166(2005)
Kajimura, N., et al. J. Struct. Biol. 139(1):27-38(2002)
Shimizu-Matsumoto, A., et al. Genomics 32(1):121-124(1996)

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