Full Product Name
PDE8B Antibody, Biotin Conjugated
Product Synonym Names
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B; EC 3.1.4.53; Cell proliferation-inducing gene 22 protein; PDE8B
Product Gene Name
anti-PDE8B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95263
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8Bprotein (18-110AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PDE8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PDE8B antibody
Signal Transduction
Applications Tested/Suitable for anti-PDE8B antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for PDE8B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001025022.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001029851.2
[Other Products]
UniProt Primary Accession #
O95263
[Other Products]
UniProt Secondary Accession #
Q5J7V7; Q86XK8; Q8IUJ7; Q8IUJ8; Q8IUJ9; Q8IUK0; Q8N3T2[Other Products]
UniProt Related Accession #
O95263[Other Products]
Molecular Weight
87,974 Da
NCBI Official Full Name
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3
NCBI Official Synonym Full Names
phosphodiesterase 8B
NCBI Official Symbol
PDE8B [Similar Products]
NCBI Official Synonym Symbols
ADSD; PPNAD3
[Similar Products]
NCBI Protein Information
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
UniProt Protein Name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
UniProt Synonym Protein Names
Cell proliferation-inducing gene 22 protein
Protein Family
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE8B [Similar Products]
UniProt Synonym Gene Names
HsPDE8B [Similar Products]
NCBI Summary for PDE8B
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
UniProt Comments for PDE8B
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
Research Articles on PDE8B
1. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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