Product Name
Aquaporin 2 (AQP2), Polyclonal Antibody
Popular Item
Full Product Name
Aquaporin 2 (Phospho-Ser256) Antibody
Product Synonym Names
ADH water channel; AQP-CD; aquaporin 2; Aquaporin-CD; Collecting duct water channel protein; Water channel protein for renal collecting duct; WCH-CD
Product Gene Name
anti-AQP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P41181
Species Reactivity
Human, Mouse, Rat
Specificity
Aquaporin 2 (Phospho-Ser256) Antibody detects endogenous levels of Aquaporin 2 only when phosphorylated at Ser256.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Phospho
Modification Sites
H:S256; M:S256; R:S256
Immunogen
The antiserum was produced against synthesized peptide derived from human Aquaporin 2 around the phosphorylation site of Ser256.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-AQP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AQP2 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AQP2 antibody
IHC: 1:50~1:100
ELISA: 1:40000
Immunohistochemistry (IHC) of anti-AQP2 antibody
Immunohistochemistry analysis of paraffin-embedded human brain, using Aquaporin 2 (Phospho-Ser256) Antibody. The picture on the right is blocked with the phospho peptide.
NCBI/Uniprot data below describe general gene information for AQP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000477.1
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NCBI GenBank Nucleotide #
NM_000486.5
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UniProt Primary Accession #
P41181
[Other Products]
UniProt Secondary Accession #
Q9UD68[Other Products]
UniProt Related Accession #
P41181[Other Products]
NCBI Official Full Name
aquaporin-2
NCBI Official Synonym Full Names
aquaporin 2
NCBI Official Symbol
AQP2 [Similar Products]
NCBI Official Synonym Symbols
AQP-CD; WCH-CD
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NCBI Protein Information
aquaporin-2
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Gene Name
AQP2 [Similar Products]
UniProt Synonym Gene Names
AQP-2; AQP-CD [Similar Products]
NCBI Summary for AQP2
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
UniProt Comments for AQP2
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Research Articles on AQP2
1. E3 ligases most likely to interact with AQP2.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
