Full Product Name
PDE8B antibody
Product Synonym Names
Polyclonal PDE8B; Anti-PDE8B; PDEB 8; cyclic nucleotide phosphodiesterase 8B; PDEB -8; pde8b; phosphodiesterase 8b; PDE8B
Product Gene Name
anti-PDE8B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95263
Purity/Purification
PDE8B antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDE1-11; PDE4, 7 and 8 selectively degrade cAMP. These enzymes are involved in many signal transduction pathways.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
PDE8B antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PDE8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PDE8B antibody
Rabbit polyclonal PDE8B antibody
Product Categories/Family for anti-PDE8B antibody
Signal Transduction
Applications Tested/Suitable for anti-PDE8B antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-PDE8B antibody
IHC-P: 10 ug/ml
NCBI/Uniprot data below describe general gene information for PDE8B. It may not necessarily be applicable to this product.
NCBI Accession #
EAW95804.1
[Other Products]
UniProt Primary Accession #
O95263
[Other Products]
UniProt Secondary Accession #
Q5J7V7; Q86XK8; Q8IUJ7; Q8IUJ8; Q8IUJ9; Q8IUK0; Q8N3T2[Other Products]
UniProt Related Accession #
O95263[Other Products]
Molecular Weight
93,674 Da
NCBI Official Full Name
phosphodiesterase 8B, isoform CRA_g
NCBI Official Synonym Full Names
phosphodiesterase 8B
NCBI Official Symbol
PDE8B [Similar Products]
NCBI Official Synonym Symbols
ADSD; PPNAD3
[Similar Products]
NCBI Protein Information
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
UniProt Protein Name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
UniProt Synonym Protein Names
Cell proliferation-inducing gene 22 protein
Protein Family
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE8B [Similar Products]
UniProt Synonym Gene Names
HsPDE8B [Similar Products]
UniProt Entry Name
PDE8B_HUMAN
NCBI Summary for PDE8B
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
UniProt Comments for PDE8B
PDE8B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Defects in PDE8B are the cause of striatal degeneration autosomal dominant (ADSD). It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. Defects in PDE8B are the cause of primary pigmented nodular adrenocortical disease type 3 (PPNAD3). PPNAD3 is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: behavioral fear response; cyclic nucleotide metabolic process; operant conditioning; cAMP catabolic process; two-component signal transduction system (phosphorelay); visual learning; neuromuscular process controlling balance; negative regulation of insulin secretion
Disease: Striatal Degeneration, Autosomal Dominant; Pigmented Nodular Adrenocortical Disease, Primary, 3
Research Articles on PDE8B
1. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism.
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