Product Name
Constitutive Androstane Receptor (CAR), Polyclonal Antibody
Full Product Name
PE-Linked Polyclonal Antibody to Constitutive Androstane Receptor (CAR)
Product Synonym Names
NR1I3; NR1-I3; CAR1; MB67; Nuclear Receptor Subfamily 1, Group I, Member 3; Constitutive active response; Constitutive activator of retinoid response; Orphan nuclear receptor MB67
Product Gene Name
anti-CAR antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Constitutive Androstane Receptor (MBS2032911)
PE Conjugated Antibody: Constitutive Androstane Receptor (CAR) (MBS2065596)
Matching Pairs
PE Conjugated Antibody: Constitutive Androstane Receptor (CAR) (MBS2065596)
Immunogen: Constitutive Androstane Receptor (MBS2033523)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
CAR (Met1~Glu247)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2032911
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-CAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CAR antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for CAR. It may not necessarily be applicable to this product.
NCBI Accession #
BAH02293.1
[Other Products]
UniProt Secondary Accession #
Q0VAC9; Q4U0F0; E9PB75; E9PC13; E9PDU3; E9PGH6; E9PH10; E9PHC8; E9PHN4; F1D8Q0; F1D8Q1[Other Products]
UniProt Related Accession #
Q14994[Other Products]
Molecular Weight
30,262 Da
NCBI Official Full Name
constitutive androstane receptor
NCBI Official Synonym Full Names
nuclear receptor subfamily 1 group I member 3
NCBI Official Symbol
NR1I3 [Similar Products]
NCBI Official Synonym Symbols
CAR; CAR1; MB67
[Similar Products]
NCBI Protein Information
nuclear receptor subfamily 1 group I member 3
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 3
UniProt Synonym Protein Names
Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67
Protein Family
Carboxylic acid reductase
UniProt Gene Name
NR1I3 [Similar Products]
UniProt Synonym Gene Names
CAR; Constitutive active response; CAR [Similar Products]
NCBI Summary for CAR
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CAR
NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: androgen receptor activity; DNA binding; ligand-dependent nuclear receptor activity; transcription coactivator activity; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
Research Articles on CAR
1. Integrative analysis of four RNA-Seq datasets and differential expression revealed for the first time, splicing alterations of SLC39A14 and NR1I3 in hepatocellular carcinoma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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