MRP2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Liquid

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-MRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

173,671 Da

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

canalicular multispecific organic anion transporter 1

Canalicular multispecific organic anion transporter 1

MRP2_MOUSE

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]

ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Cellular Component: apical plasma membrane; cell surface; integral to plasma membrane; intercellular canaliculus; membrane

Molecular Function: protein binding; protein domain specific binding

Biological Process: cellular chloride ion homeostasis; multidrug transport; prostaglandin transport; response to drug; response to estrogen stimulus

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