Follicle Stimulating Hormone Receptor, Polyclonal Antibody

Anti -Follicle Stimulating Hormone Receptor (FSH Receptor, FSHr, FSH-R, FSHRO, Follitropin Receptor, LGR1, MGC141667, MGC141668, ODG1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (49189296..49381666, complement). Location: 2p21-p16

Polyclonal

IgG

Rabbit

Recognizes human Follicle Stimulating Hormone Receptor at ~78kD. Species Crossreactivity: mouse and rat

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 50% glycerol.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-FSHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Follicle stimulating hormone receptor (FSHR) is a multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. FSHR is a receptor for follicle stimulating hormone. At least 2 isoforms arising from alternative splicing have been described.

Antibodies; Abs to Receptors

Western Blot (WB)

Suitable for use in Western Blot.

78,265 Da[Similar Products]

follicle stimulating hormone receptor

follicle-stimulating hormone receptor; FSH receptor; OTTHUMP00000159573; OTTHUMP00000159574; OTTHUMP00000200511; follitropin receptor

Follicle-stimulating hormone receptor

LGR1  [Similar Products]

FSHR_HUMAN

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p21-p16

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; follicle-stimulating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; follicle-stimulating hormone signaling pathway; gonad development; male gonad development; female gamete generation; spermatogenesis; female gonad development

Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

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