Product Name
CNBP, Recombinant Protein
Full Product Name
CNBP, 1-170aa, Human, His tag, E Coli
Product Synonym Names
Cellular nucleic acid-binding protein; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
Product Gene Name
CNBP recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSSNECF KCGRSGHWAR ECPTGGGRGR GMRSRGRGFQ FVSSSLPDIC YRCGESGHLA KDCDLQEDAC YNCGRGGHIA KDCKEPKRER EQCCYNCGKP GHLARDCDHA DEQKCYSCGE FGHIQKDCTK VKCYRCGETG HVAINCSKTS EVNCYRCGES GHLARECTIE ATA
3D Structure
ModBase 3D Structure for P62633
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 7.5) containing 0.2M NaCl, 20% glycerol, 1mM DTT.
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of CNBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CNBP recombinant protein
CNBP is a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. It functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Recombinant human CNBP protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for CNBP recombinant protein
Epigenomics
Applications Tested/Suitable for CNBP recombinant protein
SDS-PAGE
SDS-Page of CNBP recombinant protein
NCBI/Uniprot data below describe general gene information for CNBP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001120668
[Other Products]
NCBI GenBank Nucleotide #
NM_001127196.1
[Other Products]
UniProt Primary Accession #
P62633
[Other Products]
UniProt Secondary Accession #
P20694; Q4JGY0; Q4JGY1; Q5QJR0; A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7[Other Products]
UniProt Related Accession #
P62633[Other Products]
Molecular Weight
21 kDa (193aa) confirmed by MALDI-TOF
NCBI Official Full Name
cellular nucleic acid-binding protein isoform 6
NCBI Official Synonym Full Names
CCHC-type zinc finger nucleic acid binding protein
NCBI Official Symbol
CNBP [Similar Products]
NCBI Official Synonym Symbols
DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22
[Similar Products]
NCBI Protein Information
cellular nucleic acid-binding protein
UniProt Protein Name
Cellular nucleic acid-binding protein
UniProt Synonym Protein Names
Zinc finger protein 9
Protein Family
Cellular nucleic acid-binding protein
UniProt Gene Name
CNBP [Similar Products]
UniProt Synonym Gene Names
RNF163; ZNF9; CNBP [Similar Products]
NCBI Summary for CNBP
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
UniProt Comments for CNBP
Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
Product References and Citations for CNBP recombinant protein
McGrath CF, Buckman JS, et al. (2003). J Virol. 77 (15):8524-31.
Research Articles on CNBP
1. A second point is that DM mutations, although located in noncoding regions, may reduce the expression of mutant alleles, raising questions whether loss-of-function may contribute to the phenotype, or possibly impose a safety limit on knockdown therapies that create or aggravate a DMPK or CNBP deficiency state
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
