CACNA1A, Polyclonal Antibody

BI; EA2; FHM; MHP; APCA; HPCA; MHP1; SCA6; CAV2.1; CACNL1A4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1.5mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CACNA1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

Epigenetics

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:15-1:50

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CACNA1A Polyclonal Antibody at dilution 1:15

Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CACNA1A Polyclonal Antibody at dilution 1:15

267,647 Da

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

voltage-dependent P/Q-type calcium channel subunit alpha-1A; brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; leaner; rocker; tottering; voltage-gated calcium channel subunit alpha Cav2.1

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Caca1a; Cach4; Cacn3; Cacnl1a4; Ccha1a; BI  [Similar Products]

CAC1A_MOUSE

CACNA1A: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). Defects in CACNA1A are the cause of spinocerebellar ataxia type 6 (SCA6). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder. Defects in CACNA1A are the cause of familial hemiplegic migraine type 1 (FHM1); also known as migraine familial hemiplegic 1 (MHP1). FHM1, a rare autosomal dominant subtype of migraine with aura, is associated with ictal hemiparesis and, in some families, progressive cerebellar atrophy. Defects in CACNA1A are the cause of episodic ataxia type 2 (EA2); also known as acetazolamide-responsive hereditary paroxysmal cerebellar ataxia (APCA). EA2 is an autosomal dominant disorder characterized by acetozolamide- responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Cellular Component: protein complex; cell; dendrite; integral to membrane; perikaryon; cytosol; cell projection; cell soma; membrane; cytoplasm; plasma membrane; voltage-gated calcium channel complex; nucleus

Molecular Function: voltage-gated calcium channel activity; calmodulin binding; protein binding; DNA binding; syntaxin binding; calcium channel activity; metal ion binding; ion channel activity; high voltage-gated calcium channel activity; voltage-gated ion channel activity

Biological Process: cell death; vestibular nucleus development; central nervous system neuron differentiation; musculoskeletal movement, spinal reflex action; gamma-aminobutyric acid secretion; response to pain; sensory perception of pain; regulation of axonogenesis; receptor clustering; cellular chloride ion homeostasis; ***** walking behavior; synaptic transmission; behavioral response to pain; elevation of cytosolic calcium ion concentration; synaptogenesis; neurotransmitter metabolic process; transport; calcium ion transport; nerve-nerve synaptic transmission; negative regulation of neuron apoptosis; neuromuscular process controlling balance; cell growth; cerebellum maturation; transmembrane transport; thyroid hormone metabolic process; synaptic transmission, glutamatergic; rhythmic synaptic transmission; dendrite morphogenesis; neuromuscular process; regulation of acetylcholine secretion; calcium ion-dependent exocytosis of neurotransmitter; cerebellar Purkinje cell layer development; synaptic transmission, GABAergic; glucose metabolic process; transmission of nerve impulse; spinal cord motor neuron differentiation; regulation of calcium ion-dependent exocytosis; cerebellar molecular layer development; calcium ion-dependent exocytosis; neurological system process; membrane depolarization; regulation of membrane potential; sulfur amino acid metabolic process; cerebellar Purkinje cell differentiation; hormone metabolic process; neuromuscular synaptic transmission; ion transport; gamma-aminobutyric acid signaling pathway; negative regulation of hormone biosynthetic process

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