Product Name
A-kinase anchor protein 5 (Akap5), Recombinant Protein
Full Product Name
Recombinant Rat A-kinase anchor protein 5 (Akap5)
Product Gene Name
Akap5 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-714aa, Full length protein
Sequence
METSVSEIQI ETKDEKRPEA ASPQKERQER KTATLCFKRR KKVNKKKAKA GSKTAEETEK HAPEAGGSGQ RQPAGAWASI KRLVTHRKPS ESAEKQKPSE AEMQPEDGAL PKKKTKSKLK IPCIRFSRGA KRSRPSKLTE DSGYVRVQGE ADDLEIKAQI QPDEQATQAK STQGLQEDVI VRDGKEIQES HISNNVISGE HVIGIELELE KESSALRMRT PGSEKEAKVI LVKQGVQVQE ASVLENSAAD SPQPVTSTAP LSPATTHQLG LEEPSDSIRE SAPSGKDDGR RKTAAEEKKS GETALGQAEE ASSVSQADKS VLSQAEEATV GHTEEATVIQ AQSQAKEGKL SQAEEATVAQ AKETVLSQAE EVKLSQIEEP AISQAKKATV GQAKEAYVSQ AEEAIVGHTE KATMGQAEEA TVGHIEKTTV GQAEEATVGQ AEEATVGQAE EATVGQAEEA TVGQAEEATV GQAGEATVSH IEKTTVGQAE EAIVGQAEEA TVGQAEEATV GQAEEATVGQ AEEATVDQAE EATVGQAEEA TVGQAGEAAV GQAEEAIVAQ AEEATVGQAG EATVGQAEKA TVGQAEEPIV GQAEETVLRH ASDLKVNGVD AEKPRSEESK RMEPIAIIIT DTEISEFDVK KSKNVPKQFL ISMENEQVGV FANDSDFEGR TSEQYETLLI ETASSLVKNA IELSVEQLVN EMVSEDNQIN TLFQ
3D Structure
ModBase 3D Structure for P24587
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Akap5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Akap5 recombinant protein
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
NCBI/Uniprot data below describe general gene information for Akap5. It may not necessarily be applicable to this product.
NCBI Accession #
P24587.2
[Other Products]
UniProt Primary Accession #
P24587
[Other Products]
UniProt Secondary Accession #
P70593[Other Products]
UniProt Related Accession #
P24587[Other Products]
Molecular Weight
75,962 Da
NCBI Official Full Name
A-kinase anchor protein 5
NCBI Official Synonym Full Names
A-kinase anchoring protein 5
NCBI Official Symbol
Akap5 [Similar Products]
NCBI Official Synonym Symbols
P150; Akap79; AKAP150
[Similar Products]
NCBI Protein Information
A-kinase anchor protein 5
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 150 kDa; AKAP 150; P150; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Protein Family
A-kinase anchor protein
UniProt Gene Name
Akap5 [Similar Products]
UniProt Synonym Gene Names
Akap150; AKAP-5; AKAP 150; P150 [Similar Products]
UniProt Comments for Akap5
May anchor the PKA kinase to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors.
Research Articles on Akap5
1. Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
