Full Product Name
IQCB1 Antibody
Product Synonym Names
IQ calmodulin-binding motif-containing protein 1; Nephrocystin-5
Product Gene Name
anti-IQCB1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15051
Specificity
IQCB1 Antibody detects endogenous levels of total IQCB1 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human IQCB1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-IQCB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IQCB1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IQCB1 antibody
WB: 1:500~1:1000
ELISA: 1:40000
Western Blot (WB) of anti-IQCB1 antibody
Western blot analysis of lysates from K562 cells, using IQCB1 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for IQCB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001018864.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001023570.3
[Other Products]
UniProt Primary Accession #
Q15051
[Other Products]
UniProt Secondary Accession #
Q3KS08; Q3KS09; Q5DKQ7; Q8NI79; Q9BS08[Other Products]
UniProt Related Accession #
Q15051[Other Products]
NCBI Official Full Name
IQ calmodulin-binding motif-containing protein 1 isoform a
NCBI Official Synonym Full Names
IQ motif containing B1
NCBI Official Symbol
IQCB1 [Similar Products]
NCBI Official Synonym Symbols
PIQ; NPHP5; SLSN5
[Similar Products]
NCBI Protein Information
IQ calmodulin-binding motif-containing protein 1
UniProt Protein Name
IQ calmodulin-binding motif-containing protein 1
UniProt Synonym Protein Names
Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein; PIQ
Protein Family
IQ calmodulin-binding motif-containing protein
UniProt Gene Name
IQCB1 [Similar Products]
UniProt Synonym Gene Names
KIAA0036; NPHP5; PIQ [Similar Products]
NCBI Summary for IQCB1
This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Jan 2016]
UniProt Comments for IQCB1
Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655).
Research Articles on IQCB1
1. that nephrocystin-5 is essential for photoreceptor outer segment formation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
