Full Product Name
HSCB Antibody, FITC conjugated
Product Synonym Names
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial; DnaJ homolog subfamily C member 20; Hsc20; HSCB; DNAJC20; HSC20
Product Gene Name
anti-HSCB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IWL3
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Iron-sulfur cluster co-chaperone protein HscB, mitochondrial protein (30-235AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-HSCB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HSCB antibody
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.
Product Categories/Family for anti-HSCB antibody
Metabolism; Signal transduction
Applications Tested/Suitable for anti-HSCB antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for HSCB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_741999.3
[Other Products]
NCBI GenBank Nucleotide #
NM_172002.4
[Other Products]
UniProt Primary Accession #
Q8IWL3
[Other Products]
UniProt Secondary Accession #
Q9BWS7[Other Products]
UniProt Related Accession #
Q8IWL3[Other Products]
Molecular Weight
27,422 Da
NCBI Official Full Name
iron-sulfur cluster co-chaperone protein HscB, mitochondrial isoform 1
NCBI Official Synonym Full Names
HscB mitochondrial iron-sulfur cluster cochaperone
NCBI Official Symbol
HSCB [Similar Products]
NCBI Official Synonym Symbols
JAC1; HSC20; DNAJC20
[Similar Products]
NCBI Protein Information
iron-sulfur cluster co-chaperone protein HscB, mitochondrial
UniProt Protein Name
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
UniProt Synonym Protein Names
DnaJ homolog subfamily C member 20; Hsc20
Protein Family
Co-chaperone protein
UniProt Gene Name
HSCB [Similar Products]
UniProt Synonym Gene Names
DNAJC20; HSC20 [Similar Products]
NCBI Summary for HSCB
This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for HSCB
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.
Research Articles on HSCB
1. The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins; review focuses on recent insights into the molecular mechanism of amino acid motif recognition and discrimination by the co-chaperone HSC20 and finds co-chaperone HSC20 binds to LYR motifs present in Fe-S recipient proteins or their binding partners. [Review]
Precautions
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Disclaimer
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