Product Name
IFN-alphaR2, Polyclonal Antibody
Full Product Name
IFN-alphaR2 Polyclonal Antibody
Product Synonym Names
IFN-aR2 Polyclonal Antibody; IFNAR2; IFNABR; IFNARB; Interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein; Type I interferon receptor 2
Product Gene Name
anti-IFN-alphaR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48551
Specificity
IFN-aR2 Polyclonal Antibody detects endogenous levels of IFN-aR2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from the N-terminal region of human IFN-aR2.
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-IFN-alphaR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IFN-alphaR2 antibody
Total protein Ab
Applications Tested/Suitable for anti-IFN-alphaR2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IFN-alphaR2 antibody
Western Blot: 1:500 - 1:2000
ELISA: 1:20000
Not yet tested in other applications.
Western Blot (WB) of anti-IFN-alphaR2 antibody
Western Blot analysis of 293 cells using IFN-aR2 Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for IFN-alphaR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000865.2
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NCBI GenBank Nucleotide #
NM_000874.4
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UniProt Primary Accession #
P48551
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UniProt Secondary Accession #
Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9[Other Products]
UniProt Related Accession #
P48551[Other Products]
Molecular Weight
27,384 Da
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform b
NCBI Official Synonym Full Names
interferon (alpha, beta and omega) receptor 2
NCBI Official Symbol
IFNAR2 [Similar Products]
NCBI Official Synonym Symbols
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
[Similar Products]
NCBI Protein Information
interferon alpha/beta receptor 2
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Synonym Protein Names
Interferon alpha binding protein; Type I interferon receptor 2
UniProt Gene Name
IFNAR2 [Similar Products]
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
UniProt Entry Name
INAR2_HUMAN
NCBI Summary for IFN-alphaR2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for IFN-alphaR2
IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: extracellular space; integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding
Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; response to virus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade
Disease: Hepatitis B Virus, Susceptibility To
Research Articles on IFN-alphaR2
1. Lack of expression of functional IFNAR2 does not seem to be the major cause of interferon resistance in hepatitis C virus patients receiving standard interferon therapy.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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