Product Name
IFN-alphaR2, Polyclonal Antibody
Full Product Name
IFN-alphaR2 Polyclonal Antibody
Product Gene Name
anti-IFN-alphaR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48551
Other Notes
Small volumes of anti-IFN-alphaR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IFN-alphaR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000865.2
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NCBI GenBank Nucleotide #
NM_000874.4
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UniProt Primary Accession #
P48551
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UniProt Secondary Accession #
Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9[Other Products]
UniProt Related Accession #
P48551[Other Products]
Molecular Weight
27,384 Da
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform b
NCBI Official Synonym Full Names
interferon alpha and beta receptor subunit 2
NCBI Official Symbol
IFNAR2 [Similar Products]
NCBI Official Synonym Symbols
IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
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NCBI Protein Information
interferon alpha/beta receptor 2
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Synonym Protein Names
Interferon alpha binding protein; Type I interferon receptor 2
UniProt Gene Name
IFNAR2 [Similar Products]
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
NCBI Summary for IFN-alphaR2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for IFN-alphaR2
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Research Articles on IFN-alphaR2
1. Report lowered serum IFNAR2 levels in multiple sclerosis patients are elevated on treatment with interferon-beta.
Precautions
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Disclaimer
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