MYH9, Recombinant Protein

Cellular myosin heavy chain protein; type A Myosin heavy chain 9 Myosin heavy chain protein; non muscle Iia protein; Non muscle myosin heavy chain A protein; NMMHC A protein; Non muscle myosin heavy chain Iia protein; NMMHC II a protein; NMMHC IIA protein; Myosin 9 protein; MYH 9 protein; MYH-9 protein

For Research Use Only. Not for use in diagnostic procedures.

Human

> 90% pure

Supplied in liquid form in PBS buffer with 20 mM GSH

Store at 4 degree C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 degree C, avoid repeat freeze/thaw cycles

Small volumes of MYH9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Purified recombinant MYH9 protein

Cell Biology

ELISA (EIA), SDS-PAGE, Western Blot (WB)

53 kDa

myosin, heavy chain 9, non-muscle

myosin-9

Myosin-9

NMMHC-A; NMMHC II-a; NMMHC-IIA  [Similar Products]

MYH9_HUMAN

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

MYH9: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: signalosome; cortical cytoskeleton; protein complex; myosin II complex; leading edge; contractile ring; immunological synapse; actomyosin; cytosol; actin cytoskeleton; ruffle; cell-cell adherens junction; membrane; cytoplasm; plasma membrane; stress fiber; spindle; uropod; nucleus; integrin complex; neuromuscular junction; cleavage furrow

Molecular Function: calmodulin binding; actin filament binding; microfilament motor activity; protein binding; protein homodimerization activity; protein anchor; ATPase activity; motor activity; actin-dependent ATPase activity; ADP binding; actin binding; ATP binding

Biological Process: integrin-mediated signaling pathway; axon guidance; monocyte differentiation; blood vessel endothelial cell migration; in utero embryonic development; actin filament-based movement; membrane protein ectodomain proteolysis; actomyosin structure organization and biogenesis; cytokinesis; uropod organization and biogenesis; regulation of cell shape; establishment of meiotic spindle localization; protein transport; actin cytoskeleton reorganization; ephrin receptor signaling pathway; establishment of T cell polarity; angiogenesis; platelet formation; leukocyte migration; meiotic spindle organization and biogenesis; myoblast fusion

Disease: Deafness, Autosomal Dominant 17; May-hegglin Anomaly; Fechtner Syndrome; Macrothrombocytopenia And Progressive Sensorineural Deafness; Epstein Syndrome; Sebastian Syndrome

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