Product Name
CYP11A1, cDNA Clone
Popular Item
Full Product Name
CYP11A1 cDNA Clone
Product Gene Name
CYP11A1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgctggcca agggtcttcc cccacgctca gtcctggtca aaggctgcca gacctttctg agtgccccca gggaggggct ggggcgtctc agggtgccca ctggcgaggg agctggcatc tccacccgca gtcctcgccc cttcaatgag atcccctctc ctggtgacaa tggctggcta aacctgtacc atttctggag ggagacgggc acacacaaag tccaccttca ccatgtccag aatttccaga agtatggccc gatttacagg gagaagctcg gcaacgtgga gtcggtttat gtcatcgacc ctgaagatgt ggcccttctc tttaagtccg agggccccaa cccagaacga ttcctcatcc cgccctgggt cgcctatcac cagtattacc agagacccat aggagtcctg ttgaagaagt cggcagcctg gaagaaagac cgggtggccc tgaaccagga ggtgatggct ccagaggcca ccaagaactt tttgcccctg ttggatgcag tgtctcggga cttcgtcagt gtcctgcaca ggcgcatcaa gaaggcgggc tccggaaatt actcggggga catcagtgat gacctgttcc gctttgcctt tgagtccatc actaacgtca tttttgggga gcgccagggg atgctggagg aagtagtgaa ccccgaggcc cagcgattca ttgatgccat ctaccagatg ttccacacca gcgtccccat gctcaacctt cccccagacc tgttccgtct gttcaggacc aagacctgga aggaccatgt ggctgcatgg gacgtgattt tcagtaaagc tgacatatac acccagaact tctactggga attgagacag aaaggaagtg ttcaccacga ttaccgtggc atcctctaca gactcctggg agacagcaag atgtccttcg aggacatcaa ggccaacgtc acagagatgc tggcaggagg ggtggacacg acgtccatga ccctgcagtg gcacttgtat gagatggcac gcaacctgaa ggtgcaggat atgctgcggg cagaggtctt ggctgcgcgg caccaggccc agggagacat ggccacgatg ctacagctgg tccccctcct caaagccagc atcaaggaga cactaagact tcaccccatc tccgtgaccc tgcagagata tcttgtaaat gacttggttc ttcgagatta catgattcct gccaagacac tggtgcaagt ggccatctat gctctgggcc gagagcccac cttcttcttc gacccggaaa attttgaccc aacccgatgg ctgagcaaag acaagaacat cacctacttc cggaacttgg gctttggctg gggtgtgcgg cagtgtctgg gacggcggat cgctgagcta gagatgacca tcttcctcat caatatgctg gagaacttca gagttgaaat ccaacacctc agcgatgtgg gcaccacatt caacctcatt ctgatgcctg aaaagcccat ctccttcacc ttctggccct ttaaccagga agcaacccag cagtga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CYP11A1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYP11A1. It may not necessarily be applicable to this product.
NCBI Accession #
BC032329
[Other Products]
UniProt Secondary Accession #
Q15081; Q16805; Q8N1A7; A8K8D5; B3KPU8; G3XAD7[Other Products]
UniProt Related Accession #
P05108[Other Products]
Molecular Weight
42,152 Da
NCBI Official Full Name
Homo sapiens cytochrome P450, family 11, subfamily A, polypeptide 1, mRNA
NCBI Official Synonym Full Names
cytochrome P450 family 11 subfamily A member 1
NCBI Official Symbol
CYP11A1 [Similar Products]
NCBI Official Synonym Symbols
CYP11A; CYPXIA1; P450SCC
[Similar Products]
NCBI Protein Information
cholesterol side-chain cleavage enzyme, mitochondrial
UniProt Protein Name
Cholesterol side-chain cleavage enzyme, mitochondrial
UniProt Synonym Protein Names
CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
Protein Family
Cholesterol side-chain cleavage enzyme
UniProt Gene Name
CYP11A1 [Similar Products]
UniProt Synonym Gene Names
CYP11A [Similar Products]
UniProt Entry Name
CP11A_HUMAN
NCBI Summary for CYP11A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP11A1
CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family.
Protein type: Lipid Metabolism - C21-steroid hormone; EC 1.14.15.6; Oxidoreductase; Mitochondrial
Chromosomal Location of Human Ortholog: 15q23-q24
Cellular Component: mitochondrial inner membrane; mitochondrial matrix; mitochondrion
Molecular Function: cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
Biological Process: C21-steroid hormone biosynthetic process; cholesterol metabolic process; glucocorticoid biosynthetic process; sterol metabolic process; vitamin D metabolic process
Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
Research Articles on CYP11A1
1. An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the predisposition to childhood asthma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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