Full Product Name
ACOX2 Antibody
Product Synonym Names
BCOX; BRCOX; THCCox; BRCACOX
Product Gene Name
anti-ACOX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99424
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total ACOX2 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.8 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human Acyl-CoA oxidase 2, branched chain
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ACOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACOX2 antibody
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children.
Product Categories/Family for anti-ACOX2 antibody
Total protein Ab
Applications Tested/Suitable for anti-ACOX2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACOX2 antibody
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Testing Data of anti-ACOX2 antibody
Gel: 8%SDS-PAGE Lysates (from left to right): Mouse liver and kidney tissue Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes
Immunohistochemistry (IHC) of anti-ACOX2 antibody
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/20.
NCBI/Uniprot data below describe general gene information for ACOX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003491.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003500.3
[Other Products]
UniProt Primary Accession #
Q99424
[Other Products]
UniProt Secondary Accession #
A6NF16; B2R8U5[Other Products]
UniProt Related Accession #
Q99424[Other Products]
Molecular Weight
76,827 Da
NCBI Official Full Name
peroxisomal acyl-coenzyme A oxidase 2
NCBI Official Synonym Full Names
acyl-CoA oxidase 2, branched chain
NCBI Official Symbol
ACOX2 [Similar Products]
NCBI Official Synonym Symbols
BCOX; BRCOX; THCCox; BRCACOX
[Similar Products]
NCBI Protein Information
peroxisomal acyl-coenzyme A oxidase 2
UniProt Protein Name
Peroxisomal acyl-coenzyme A oxidase 2
UniProt Synonym Protein Names
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox
Protein Family
Peroxisomal acyl-coenzyme A oxidase
UniProt Gene Name
ACOX2 [Similar Products]
UniProt Synonym Gene Names
THCA-CoA oxidase; THCCox [Similar Products]
UniProt Entry Name
ACOX2_HUMAN
NCBI Summary for ACOX2
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]
UniProt Comments for ACOX2
ACOX2: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Belongs to the acyl-CoA oxidase family.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; EC 1.17.99.3
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: peroxisomal matrix; peroxisome
Molecular Function: acyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; acyl-CoA oxidase activity; FAD binding; pristanoyl-CoA oxidase activity; receptor binding
Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; bile acid metabolic process; cellular lipid metabolic process
Research Articles on ACOX2
1. Our results suggest that downregulation of ACOX2 is a shared risk factor for PE and CVD.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
