Product Name
4.1R (Phospho-Tyr660) (EPB41), Polyclonal Antibody
Full Product Name
4.1R (Phospho-Tyr660) Polyclonal Antibody
Product Synonym Names
EPB41; E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1
Product Gene Name
anti-EPB41 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11171
Species Reactivity
Human, Mouse
Specificity
Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from human 4.1R around the phosphorylation site of Y660.
Modification
Phospho-Tyr660
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-EPB41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-EPB41 antibody
Phospho-specific Ab
Applications Tested/Suitable for anti-EPB41 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-EPB41 antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
ELISA: 1:5000
Not yet tested in other applications
Western Blot (WB) of anti-EPB41 antibody
Western Blot analysis of JK cells using Phospho-4.1R (Y660) Polyclonal Antibody
Western Blot (WB) of anti-EPB41 antibody
Western Blot analysis of Jurkat cells using Phospho-4.1R (Y660) Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for EPB41. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001159477.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001166005.1
[Other Products]
UniProt Primary Accession #
P11171
[Other Products]
UniProt Secondary Accession #
P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579; B1ALH8; B1ALH9; D3DPM9; D3DPN0[Other Products]
UniProt Related Accession #
P11171[Other Products]
Molecular Weight
81,235 Da[Similar Products]
NCBI Official Full Name
protein 4.1 isoform 1
NCBI Official Synonym Full Names
erythrocyte membrane protein band 4.1
NCBI Official Symbol
EPB41 [Similar Products]
NCBI Official Synonym Symbols
HE; EL1; 4.1R
[Similar Products]
NCBI Protein Information
protein 4.1
UniProt Protein Name
Protein 4.1
UniProt Synonym Protein Names
4.1R; Band 4.1; EPB4.1
Protein Family
Erythroid protein
UniProt Gene Name
EPB41 [Similar Products]
UniProt Synonym Gene Names
E41P; P4.1 [Similar Products]
UniProt Entry Name
41_HUMAN
NCBI Summary for EPB41
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for EPB41
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
Research Articles on EPB41
1. Calcium mediates the conformation-based 4.1R FERM domain binding to membrane proteins by calmodulin.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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